A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo

Huang, Lina; Chen, Yu; Zhao, Yu-Qiang; Wang, Yumin; Xiong, Junwei; Zhang, Junfeng; Wu, Xianghua; Zhou, Ying

doi:10.1016/j.cclet.2020.06.006

Cited by 31 publications

(6 citation statements)

References 56 publications

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“…Accurate diagnosis of disease is always an important concern in clinics, which urgently need an effective tool for early, rapid, and accurate identification, especially for cancer, neurodegenerative diseases, cardiovascular diseases, cerebrovascular diseases, and organism injury. − In recent years, fluorescent sensors have attracted more and more interest in the area of biology, physiology, and environmental science, − especially conferring advantages in the detection of metal ions, , small molecules, − and proteins − due to simple procedures, high sensitivity, excellent specificity, in situ and real-time detection, and so forth. − Notably, some fluorescent sensors have been developed to analyze disease biomarkers, and then proceed to diagnose and treat, track pathological processes, navigate surgical resection of the tumor, and so forth. − …”

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confidence: 99%

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

et al. 2021

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Drug-induced liver injury (DILI) is a persistent concern in drug discovery and clinical medicine. The current clinical methods to assay DILI by analyzing the enzymes in serum are still not optimal. Recent studies showed that fluorescent sensors would be efficient tools for detecting the concentration and distribution of DILI indicators with high sensitivity and specificity, in real-time, in situ, and with low damage to biosamples, as well as diagnosing DILI. This review focuses on the assessment of DILI, introduces the current mechanisms of DILI, and summarizes the design strategies of fluorescent sensors for DILI indicators, including ions, small molecules, and related enzymes. Some challenges for developing DILI diagnostic fluorescent sensors are put forward. We believe that these design strategies and challenges to evaluate DILI will inspire chemists and give them opportunities to further develop other fluorescent sensors for accurate diagnoses and therapies for other diseases.

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confidence: 99%

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

et al. 2021

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“…For instance, fusing a naphthalimide dye to an indole moiety produced 22, which is a ratiometric fluorescent Fe(II) probe with emission in the NIR region and capable of detecting exogenously added Fe(II) in HeLa cells and C. elegans worms. 85 Probe FeP1 (23) was developed as a dansyl fluorophore variant, but Lipofectamine3000 was required for entry into human esophageal squamous carcinoma cells (Kyse180). 86 Dye RAcy (24), an esterase-cleavable rhodamine variant, was established and applied for distinguishing labile Fe(II) in live versus dead human cervical carcinoma cell line (HeLa) and for imaging exogenously added iron in Kunming mice.…”

Section: Activity-based Fe(ii) Sensors Based On N-oxidementioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

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Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity-and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals: iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals. CONTENTS5908 8.2. Activity-Based Fluorescent Sensors for Ni(II) 5911 9. Outlook 5911 Author Information 5912 Corresponding Authors 5912

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“…7b). 21 More recently, Xuhong Qian's group described the first cyanine based on fused ANI/indole hybrids. 24 They demonstrated that it is possible to alkylate fused ANI/indole hybrids by opening the propane sultone.…”

Section: Benzimidazole Benzothiazole Benzoxazole and Indole Hybrids O...mentioning

confidence: 99%

The how and why of naphthalimide/heterocycle-fused hybrid dyes: an overview of the latest developments in the quest for dyes with innovative optical properties

Chevalier

2023

Org. Biomol. Chem.

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A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo

Cited by 31 publications

References 56 publications

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

The how and why of naphthalimide/heterocycle-fused hybrid dyes: an overview of the latest developments in the quest for dyes with innovative optical properties

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