The numerical computation of matrix functions such as f (A)V , where A is an n × n large and sparse square matrix, V is an n × p block with p ≪ n and f is a nonlinear matrix function, arises in various applications such as network analysis ( f (t) = exp(t) or f (t) = t 3 ), machine learning ( f (t) = log(t)), theory of quantum chromodynamics ( f (t) = t 1/2 ), electronic structure computation, and others. In this work, we propose the use of global extended-rational Arnoldi method for computing approximations of such expressions. The derived method projects the initial problem onto an global extended-rational Krylov sub-An adaptive procedure for the selection of shift parameters {s 1 , . . . , s m } is given. The proposed method is also applied to solve parameter dependent systems. Numerical examples are presented to show the performance of the global extended-rational Arnoldi for these problems.