A Ray of Hope for Tender Joints: Vitamin D and Rheumatoid Arthritis

Cherniack, E. Paul

doi:10.3899/jrheum.100792

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Our results are consistent with some studies [5, 8–10, 12, 21, 29, 37, 38], while others did not find any significant relationship between RA and low vitamin D levels [7, 11, 39, 40]. This relationship may be related to latitude as it was described.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Hajjaj–Hassouni

Mawani

Allali

et al. 2017

International Journal of Rheumatology

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The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 [0.1–151]. Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients. 43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (p < 0.001). Finally, our study shows that the status of low levels of vitamin D is common in RA in different countries and under different latitudes. Absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency. Low levels of vitamin D were associated with patients characteristics (age, BMI, and educational level), RA (disease activity and corticosteroid dosage), and comorbidities (lung disease and osteoporosis therapy). This suggests the need for a particular therapeutic strategy to improve vitamin D status in RA patients.

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Section: Discussionsupporting

confidence: 93%

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Hajjaj–Hassouni

Mawani

Allali

et al. 2017

International Journal of Rheumatology

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“…29 Cherniak also studied that 84% prevalence of vitamin D3 insufficiency (serum level <30 ng/ml) in RA patients. 30 The strong point it was a prospective case-control study in case and control there was age and sex match. There are some weak points in our study, the selection of cases was not through random sampling and certainly, there was selection bias.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D3 level and rheumatoid arthritis patients attending Rizgary Teaching Hospital in Erbil city

Hamad¹,

Media

2017

ZJMS

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The History and Future of Probenecid

et al. 2011

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Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. It is still used for its uricosuric properties in the treatment in gout, but its clinical relevance has sharply fallen and is rarely used today for either. Interestingly, throughout the last 60 years, there have been a host of apparently unrelated studies using probenecid in the clinical and basic research arena, including its potential use in the diagnosis and treatment of depression and its use to prevent fura-2 leakage in calcium transient studies. Recently, it has been shown that it is also an agonist of the Transient Receptor Potential Vanilloid 2 channel. Due to its unique action and new findings implicating TRPV channels in physiology and in disease, probenecid may have a new future as a research tool, and perhaps as a clinical agent in the neurology and cardiology fields. We review the history of probenecid in this paper and its potential future uses.

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A Ray of Hope for Tender Joints: Vitamin D and Rheumatoid Arthritis

Cited by 5 publications

References 20 publications

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Relationship between vitamin D3 level and rheumatoid arthritis patients attending Rizgary Teaching Hospital in Erbil city

The History and Future of Probenecid

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