A RCT Comparing Specific Intensive Cognitive Training to Aspecific Psychological Intervention in RRMS: The SMICT Study

Mattioli, Flavia; Stampatori, Chiara; Bellomi, Fabio; Danni, Maura; Compagnucci, Laura; Uccelli, Antonio; Pardini, Matteo; Santuccio, Giuseppe; Fregonese, Giuditta; Pattini, Marianna; Allegri, Beatrice; Clerici, Raffaella; Lattuada, Annalisa; Montomoli, Cristina; Corso, Barbara; Capra, Ruggero

doi:10.3389/fneur.2014.00278

Cited by 27 publications

(40 citation statements)

References 32 publications

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“…Bonavita et al [59], noted significant pre-to post treatment improvements in a RehaCom treated MS cohort, on mental information processing, executive functions and attention. This and other similar studies have reported positive outcomes in MS patients treated with this software, and moreover, associations between functional neuroimaging (f-MRI) findings with changes in neurocognitive measures have been reported [59][60][61]. In a multicenter Italian study, RehaCom was utilized to provide specific intensive cognitive training for 12 months.…”

Section: Cognitive Neurorehabilitation In Multiple Sclerosismentioning

confidence: 79%

Neuropsychological Functions and Cognitive Neurorehabilitation in Multiple Sclerosis

Messinis¹,

Nasios²,

Papathanasopouos³

2019

Multiple Sclerosis [Working Title]

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Although cognitive difficulties are not frequently reported by patients among the initial symptoms of Multiple Sclerosis (MS), there is sufficient evidence that cognitive impairment is present from the early stage of the disease. Today it is commonly accepted that roughly one-half of individuals with MS will experience cognitive dysfunction over the course of the disease. Though MS was originally considered a disease of white matter, more recent investigations with advanced immunohistochemistry techniques have revealed that demyelination of gray matter is a common neuropathological feature in MS contributing significantly to cognitive impairment. However, despite now been recognized as a core symptom of MS, evidence up till now is only modest regarding the efficacy of pharmacological agents on cognitive dysfunction and non-pharmacological interventions such as cognitive rehabilitation also provide incomplete evidence on whether they might improve or stabilize cognitive impairment and especially over long follow up periods. Despite this general consensus, there are studies that have reported the efficacy of cognitive neurorehabilitation in reducing MS associated cognitive deficits. In this chapter we provide a selective review of the most relevant features related to this topic.

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Section: Cognitive Neurorehabilitation In Multiple Sclerosismentioning

confidence: 79%

Neuropsychological Functions and Cognitive Neurorehabilitation in Multiple Sclerosis

Messinis¹,

Nasios²,

Papathanasopouos³

2019

Multiple Sclerosis [Working Title]

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“…[125][126][127][128][129][130][131] Restitutive cognitive training is aimed at directly treating the impaired function and should be deficit-specific. 132,133 On the other hand, learning compensatory strategies indirectly treats impaired functions. For example, the MEMREHAB (Memory Rehabilitation) trial, 134 a recent RCT not included in the two Cochrane reviews mentioned above, showed that teaching the systematic use of context information and visual imagery over 10 sessions facilitated the acquisition of new verbal information in a group of patients with clinically definite MS, not only in neuropsychological tests, but also in everyday situations.…”

Section: Treatmentmentioning

confidence: 99%

Cognitive Impairment in Multiple Sclerosis: Clinical Manifestation, Neuroimaging Correlates, and Treatment

et al. 2016

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Cognitive impairment is found in up to 70% of patients with multiple sclerosis (MS). Once thought of as a variant of subcortical dementia with a characteristic set of deficits, we now know that MS-related cognitive impairment can have many faces. This conceptual change in neuropsychology is embedded in a paradigm shift in the neuroscientific understanding of MS over the past 25 years: Partly based on modern neuroimaging techniques, the classical view of MS as an inflammatory demyelinating disease affecting the white matter of the central nervous system has been extended. In particular, many studies have shown that the MS pathology also includes neurodegeneration, and that gray matter structures such as the cerebral cortex can also show focal lesions, atrophy, or both. The authors present an updated summary of the clinical manifestation and neuroimaging correlates of cognitive impairment in MS, and discuss the relatively few treatment options available to date.

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“…For example, the efficacy of exercise training and cognitive rehabilitation interventions on walking and cognition might differentially depend on clinical characteristics, such as disability status 80 or domain of cognitive impairment. 65,75 Nevertheless, there is much that can be learned from the gerontology literature and applied in a novel manner for managing cognitive and motor outcomes independently and collectively using exercise training and cognitive rehabilitation in MS.…”

Section: Cognitive-motor Coupling and Cross-modality Transfer Effectsmentioning

confidence: 99%

Exercise Training and Cognitive Rehabilitation

Motl

Sandroff

DeLuca

2015

Neurorehabil Neural Repair

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The current review develops a rationale and framework for examining the independent and combined effects of exercise training and cognitive rehabilitation on walking and cognitive functions in persons with multiple sclerosis (MS). To do so, we first review evidence for improvements in walking and cognitive outcomes with exercise training and cognitive rehabilitation in MS. We then review evidence regarding cognitive-motor coupling and possible cross-modality transfer effects of exercise training and cognitive rehabilitation. We lastly present a macro-level framework for considering mechanisms that might explain improvements in walking and cognitive dysfunction with exercise and cognitive rehabilitation individually and combined in MS. We conclude that researchers should consider examining the effects of exercise training and cognitive rehabilitation on walking, cognition, and cognitive-motor interactions in MS and the possible physiological and central mechanisms for improving these functions.

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A RCT Comparing Specific Intensive Cognitive Training to Aspecific Psychological Intervention in RRMS: The SMICT Study

Cited by 27 publications

References 32 publications

Neuropsychological Functions and Cognitive Neurorehabilitation in Multiple Sclerosis

Neuropsychological Functions and Cognitive Neurorehabilitation in Multiple Sclerosis

Cognitive Impairment in Multiple Sclerosis: Clinical Manifestation, Neuroimaging Correlates, and Treatment

Exercise Training and Cognitive Rehabilitation

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