A Re-Evaluation of Allometric Relationships for Circulating Concentrations of Glucose in Mammals

Scanes, Colin G.

doi:10.4236/fns.2016.74026

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…While several previous studies have tested the association between blood glucose concentration and body mass in birds and mammals, these have produced inconsistent results, reporting either negative or absent correlations (Beuchat & Chong, 1998;Braun & Sweazea, 2008;Kjeld & Ólafsson, 2008;Scanes, 2016;Umminger, 1975). These studies were mostly based on values from captive individuals, however, and their glucose levels often differ from their free-living counterparts (Casado, Balbontin, & Ferrer, 2002;Ferrer & Dobado-Berrios, 1998).…”

Section: (A) (B) (C)mentioning

confidence: 99%

“…Nevertheless, several previous comparative studies have explored how blood glucose concentration relates to body mass, which is one of the major factors determining species life history (Dobson & Oli, 2007;Jeschke & Kokko, 2009;Stearns, 1992). These studies provided inconsistent results, however, reporting either negative or absent correlations between blood glucose and body mass in both birds and mammals (Beuchat & Chong, 1998;Braun & Sweazea, 2008;Kjeld & Ólafsson, 2008;Scanes, 2016;Umminger, 1975). Alternatively, indirect support for inclusion of blood glucose into POLS may be drawn from research into the relationship between blood glucose concentration and metabolic rate, as metabolic rate is considered a major physiological POLS component.…”

Section: Introductionmentioning

confidence: 99%

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Fuel for the pace of life: Baseline blood glucose concentration co‐evolves with life‐history traits in songbirds

et al. 2018

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It has been proposed that life histories have co‐evolved with a suite of physiological and behavioural adaptations, termed pace‐of‐life syndromes. Here, we hypothesise that basal concentration of blood glucose (G0), a major source of energy circulating in blood, may constitute a key component of pace‐of‐life syndromes. To test this hypothesis, we measured G0 in 30 passerine species and tested its covariation with body mass and other life‐history traits. Importantly, body mass is a major life‐history determinant and, when its effect is controlled for, there may be no single fast–slow life‐history continuum in birds comprising both fecundity and life span. Hence, we used individual life‐history traits, rather than principal component analysis, to characterise life‐history variation in our analysis. In support of G0‐life‐history co‐evolution, we found G0 to be negatively correlated with body mass and positively with reproductive investment in a single clutch across 30 passerine species. Higher G0 in females suggests that the energy demands of clutch production and incubation may be an important selection force driving co‐evolution of G0 with reproductive output. In contrast, G0 was not associated with maximum life span, suggesting that high G0 may not constrain evolution of longevity. This implies that long‐lived species can evolve physiological adaptations preventing harmful effects of high glucose concentrations, known to cause pathologies and accelerate ageing. In addition, G0, but not basal metabolic rate (BMR), was negatively correlated with migration distance, attesting to evolutionary changes in energy metabolism in long‐distance migrants. Our results further suggest that the links between body mass, reproduction and G0 are not mediated by BMR and that G0 is associated with fast–slow life‐history variation more closely than available BMR data. A species life history is determined to a great extent by body mass. When this effect is controlled for, only those traits related to reproduction (but not life span) constitute the principal axis of life‐history variation in birds. Hence, the co‐evolution of G0 with body mass and reproductive output evidenced in our study indicates that G0 constitutes an important physiological component of pace‐of‐life syndromes. A http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13238/suppinfo is available for this article.

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Section: (A) (B) (C)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fuel for the pace of life: Baseline blood glucose concentration co‐evolves with life‐history traits in songbirds

et al. 2018

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“…An identical result was obtained when restricting the analysis to domestic dog strains, although dog breeds vary widely in body size [ 44 ]. This suggests that glycation is a variable likely reflecting a biological feature that stands above a simple body condition index, as it has been recently suggested for glycaemia [ 45 , 46 ], a hypothesis that needs a broader exploration at the inter- and intraspecific levels.…”

Section: Exploring the Links Between Glycation And Life-history Trait...mentioning

confidence: 88%

Glycation resistance and life-history traits: lessons from non-conventional animal models

Duval,

Criscuolo,

Bertile

2024

Biol. Lett.

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Glycation reactions play a key role in the senescence process and are involved in numerous age-related pathologies, such as diabetes complications or Alzheimer’s disease. As a result, past studies on glycation have mostly focused on human and laboratory animal models for medical purposes. Very little is known about glycation and its link to senescence in wild animal species. Yet, despite feeding on high-sugar diets, several bat and bird species are long-lived and seem to escape the toxic effects of high glycaemia. The study of these models could open new avenues both for understanding the mechanisms that coevolved with glycation resistance and for treating the damaging effects of glycations in humans. Our understanding of glycaemia’s correlation to proxies of animals’ pace of life is emerging in few wild species; however, virtually nothing is known about their resistance to glycation, nor on the relationship between glycation, species’ life-history traits and individual fitness. Our review summarizes the scarce current knowledge on the links between glycation and life-history traits in non-conventional animal models, highlighting the predominance of avian research. We also investigate some key molecular and physiological parameters involved in glycation regulation, which hold promise for future research on fitness and senescence of individuals.

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“…Body mass is one of the main factors affecting life history, with higher body mass associated with “slower” strategies and vice versa [58]. Previous studies have reported a negative relationship between body mass and glycaemia [59][31][12][13], although [46] and [60] found non-significant trends in birds). Therefore, we predicted that bird species that live longer, develop more slowly and invest less per reproductive event should show lower plasma glucose levels and albumin glycation rates.…”

Section: Introductionmentioning

confidence: 99%

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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The pace of life hypothesis (POL) suggests that organisms’ life history, physiological and behavioural traits should co-evolve. In this context, glycaemia (i.e., blood glucose levels) and its consequences to ageing through its reaction with proteins and other compounds (i.e. glycation) constitute physiological traits which remain under-investigated in an evolutionary comparative framework, notably in relation to life history traits and ecological factors. Although their blood glucose levels are twice as high as in mammals, birds live longer when accounting for their body mass. We thus performed a comparative analysis on glucose and albumin glycation rates on 87 bird species from 22 orders, in relation to life history traits (body mass, clutch mass, maximum lifespan and developmental time) and diet. Glucose levels correlated positively with albumin glycation rates in a non-linear fashion, suggesting resistance to glycation in species with higher glucose levels. Plasma glucose levels decreased with increasing body mass and increased with maximum lifespan before reaching a plateau. Finally, terrestrial carnivores showed higher albumin glycation compared to omnivores. Our results open an important new avenue of research to help us to better understand the striking condition of hyperglycaemic yet long-lived birds.

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A Re-Evaluation of Allometric Relationships for Circulating Concentrations of Glucose in Mammals

Cited by 8 publications

References 13 publications

Fuel for the pace of life: Baseline blood glucose concentration co‐evolves with life‐history traits in songbirds

Fuel for the pace of life: Baseline blood glucose concentration co‐evolves with life‐history traits in songbirds

Glycation resistance and life-history traits: lessons from non-conventional animal models

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

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