1986
DOI: 10.1016/0306-9877(86)90082-4
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A re-evaluation of nutritional goals -not just deficiency counts

Abstract: There is considerable controversy about the soundness and relevance of so-called "megavitamin" therapy for various illnesses. In this article it is suggested that this disagreement is caused to a large extent by the use of two very different approaches to nutrition, which are referred to here as the "nutritional need" and "optimal intake" approaches. It is clear that a re-evaluation of the goals of nutrition is required, as nutritional recommendations deal mainly with the prevention of deficiency diseases and … Show more

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Cited by 9 publications
(11 citation statements)
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“…The nutritional recommendation for vitamin C, 60 mg/day [27], is not based on clinical or epidemiological studies suggesting that such a dose would be the best for health in the long term; rather, the only criterion is that such a dose prevents overt scurvy with an ample safety margin [11,[27][28][29][30][31][32][33]. Vitamin C participates in a number of enzymatic and nonenzymatic reactions [20,[32][33][34][35], and consequently it is quite possible that the physiological effects of the vitamin are not limited to the prevention of overt scurvy.…”
Section: Discussionmentioning
confidence: 99%
“…The nutritional recommendation for vitamin C, 60 mg/day [27], is not based on clinical or epidemiological studies suggesting that such a dose would be the best for health in the long term; rather, the only criterion is that such a dose prevents overt scurvy with an ample safety margin [11,[27][28][29][30][31][32][33]. Vitamin C participates in a number of enzymatic and nonenzymatic reactions [20,[32][33][34][35], and consequently it is quite possible that the physiological effects of the vitamin are not limited to the prevention of overt scurvy.…”
Section: Discussionmentioning
confidence: 99%
“…The goal of nutritional recommendations is to prevent overt scurvy and for that purpose the recommendation of 30-60 mg/day provides a good margin of safety. However, these recommendations are not based either on clinical or epidemiological studies suggesting that 30 or 60 mg/day is an optimal dose for human beings in the long term, or on biochemical studies suggesting that such doses would saturate the numerous vitamin C dependent reactions (7,11,14,15,20,24,29,33). The studies analyzed in this paper suggest that there may be groups of people who benefit from doses larger than those officially recommended.…”
Section: Discussionmentioning
confidence: 97%
“…However, it has been previously proposed that there also are conceptually much deeper problems in the interpretation of the results, at the paradigm level, to use Thomas Kuhn's terminology (44)(45)(46). Traditionally it has been assumed that vitamin C only prevents scurvy and apparently this notion has created strong prejudices against all other physiologic effects produced by this vitamin (11,44,45).…”
Section: Conceptual Problems In the Interpretation Of Common Cold Stumentioning
confidence: 99%
“…For example, they have been disregarded in the recommended dietary allowances monograph on nutritional recommendations (20), which is concerned only with the prevention of overt scurvy (41,44,45,(62)(63)(64)(65)(66)(67)(68)(69). It is noteworthy and quite surprising that in this influential monograph, Chalmers' review (23) and Dykes and Meier's review (24) are used as the basis for claiming that vitamin C has no proven effects on the common cold (20), although some of the notable shortcomings of both reviews should have been apparent to anyone familiar with the original publications.…”
Section: Open Questionsmentioning
confidence: 99%