A Re-Evaluation of the Tissue-Specific Pattern of Expression of the Rat Kallikrein Gene Family

Clements, Judith A.; Mukhtar, A; Ehrlich, Allison R.; Fuller, Peter J.

doi:10.1007/978-3-0348-7321-5_5

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…The location of tK on specific germ cells and in the epididymis is also in line with the detection of tK activity within the seminiferous tubule and epididymal duct of the rat (Blasini et al, 1980). In addition, the localization of tK mRNA in the rat testis by Clements et al (1992) underlined our findings. The orientation of tK to the apical surface of the epithelial cells of the epididymis suggests a luminal secretion.…”

Section: Discussionsupporting

confidence: 89%

“…In the rat, expression of the XLXI gene has been also detected in testis, ovary and uterus (Clements et al, 1992;Valdes et al, 1996). In the rat, expression of the XLXI gene has been also detected in testis, ovary and uterus (Clements et al, 1992;Valdes et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…True tissue or glandular kallikrein is expressed predominantly in the salivary gland, pancreas and kidney. In the rat, expression of the KLK1 gene has been also detected in testis, ovary and uterus (Clements et al, 1992;Valdes et al, 1996). The presence of tK in these reproductive organs is underlined by the occurrence of respective immunoactivity or enzyme activity (Clements, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat

et al. 2003

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The setting of a local tissue kallikrein kinin system (tKKS) within the reproductive organs of the male rat was investigated by analysing bradykinin subtype 2 receptor (B2R) gene expression and cellular distribution of B2R protein and the kinin-liberating protease tissue kallikrein (tK). Reverse transcription-polymerase chain reaction showed B2R expression in testis, epididymis and prostate from prepubertal and sexually mature rats. In mature testis, in situ hybridization and immunohistochemistry localized B2R mRNA and protein besides endothelial cells of blood vessels exclusively on pachytene spermatocytes and round and elongated spermatids. B2R expression within the seminiferous tubules was found to be dependent on the stage of the spermatogenic cycle. In pre-pubertal rat testis, B2R mRNA and protein were additionally located in peritubular cells. In the testis, specific staining for tK occurred in addition to endothelial cells of blood vessels on the acrosomal cap of round and elongated spermatids. This immunostaining was also stage-dependent. In the epididymis, tK was detected on epithelial cells near the apical surface. The stage-dependent specific expression of tK and bradykinin B2Rs in developing germ cells and peritubular cells suggests a potential role of the tKKS in the local regulation of spermatogenesis and seminiferous tubule function.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat

et al. 2003

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“…Tissue kallikreins is a member of a multigene family that shows different patterns of tissue specific gene expression ( (Clements et al, 1992). Under physiological conditions, tissue kallikrein is present in the highest concentration in exocrine glands, mostly in salivary glands and pancreas (Wolf et al, 1998).…”

Section: Tissue Kallikreins and Kininsmentioning

confidence: 99%

Kallikrein – Kinin System and Coagulation System in Inflammatory Bowel Diseases

Stadnicki¹

2011

Ulcerative Colitis - Epidemiology, Pathogenesis and Complications

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“…3,4 Plasma kallikrein exists as a zymogen, prekalliktein (PK), 75% of which circulates in the blood in a noncovalent complex with high molecular weight kininogen (HK). Under physiological conditions, tissue kallikrein is present in the highest concentration in exocrine glands, mostly in salivary glands and pancreas.…”

mentioning

confidence: 99%

Intestinal tissue kallikrein-kinin system in inflammatory bowel disease

Stadnicki

2011

Inflammatory Bowel Diseases

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Tissue kallikrein cleaves kininogens to release kinins. Kinins mediate inflammation by activating constitutive bradykinin receptor-2 (BR2), which are rapidly desensitized, and induced by inflammatory cytokines bradykinin receptor-1 (BR1), resistant to desensitization. Intestinal tissue kallikrein (ITK) may hydrolyze growth factors and peptides, whereas kinins are responsible for capillary permeability, pain, synthesis of cytokines, and adhesion molecule-neutrophil cascade. Our and others results have demonstrated ITK in intestinal goblet cells and its release into interstitial space during inflammation. Kallistatin, an inhibitor of ITK, has been shown in epithelial and goblet cells, and was decreased in inflamed intestine as well as in plasma compared with noninflammatory controls. BR1 was upregulated in patients with inflammatory bowel disease (IBD), and it has expressed in an apical part of enterocytes in inflamed intestine, but in the basal part in normal intestine. ITK and BR1 were visualized in macrophages forming granuloma in Crohn's disease. In animal studies BR2 blockade decreased intestinal contraction, but had limited effect on inflammatory lesions. BR1 was found to be upregulated in animal inflamed intestine, in part dependent on tumor necrosis factor alpha (TNF-α). A selective BR1 receptor antagonist decreased morphological and biochemical features of experimental intestinal inflammation. Both BR1 and BR2 mediate epithelial ion transport that leads to secretory diarrhea. The upregulation of BR1 in inflamed intestine provides a structural basis for the kinins function, suggesting that a selective BR1 antagonist may have potential in therapeutic trial of IBD patients.

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A Re-Evaluation of the Tissue-Specific Pattern of Expression of the Rat Kallikrein Gene Family

Cited by 11 publications

References 9 publications

Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat

Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat

Kallikrein – Kinin System and Coagulation System in Inflammatory Bowel Diseases

Intestinal tissue kallikrein-kinin system in inflammatory bowel disease

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A Re-Evaluation of the Tissue-Specific Pattern of Expression of the Rat Kallikrein Gene Family

Cited by 11 publications

References 9 publications

Tissue kallikrein and bradykinin B2receptors in the reproductive tract of the male rat

Tissue kallikrein and bradykinin B2receptors in the reproductive tract of the male rat

Kallikrein – Kinin System and Coagulation System in Inflammatory Bowel Diseases

Intestinal tissue kallikrein-kinin system in inflammatory bowel disease

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Product

Resources

About

Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat

Tissue kallikrein and bradykinin B₂receptors in the reproductive tract of the male rat