A Reactive 1O2 - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer

Wang, Xiaojun; Meng, Guoqing; Song, Zhaobin; Liu, Xinli

doi:10.1038/srep29911

Cited by 35 publications

(16 citation statements)

References 52 publications

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“…They can control the activation of PSs by adjusting the distance of PS and quencher [154]. Many stimuli, such as external stimuli (e.g., light [155]) and internal environment of tumor (e.g., pH [135,139,156,157,158,159,160,161,162,163], enzyme [91,164], GSH [165,166,167,168], and ROS [169,170,171,172,173,174,175,176]), have been used as the keys to turn on the PSs by increasing the distance among the PSs.…”

Section: Administration Of Pssmentioning

confidence: 99%

Functional Polymer Nanocarriers for Photodynamic Therapy

Yan

2018

Pharmaceuticals

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Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.

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Section: Administration Of Pssmentioning

confidence: 99%

Functional Polymer Nanocarriers for Photodynamic Therapy

Yan

2018

Pharmaceuticals

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“…Further, thioketal-based drug delivery systems are widely reported in ROS triggered drug release 111 and in hybridized PDT-chemotherapy studies. 112 The stability of the thioketal bond under physiological conditions and its triggered cleavage only in the presence of ROS species could help to reduce off-target release of the cytotoxic drug. Thus, such properties make the thioketal linker a good choice for PDT-based chemotherapy.…”

Section: Thioketal-based Linkersmentioning

confidence: 99%

Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery

Yang

Pan

Choudhury

et al. 2020

Medicinal Research Reviews

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Smart drugs, such as antibody-drug conjugates, for targeted therapy rely on the ability to deliver a warhead to the desired location and to achieve activation at the same site. Thus, designing a smart drug often requires proper linker chemistry for tethering the warhead with a vehicle in such a way that either allows the active drug to retain its potency while being tethered or ensures release and thus activation at the desired location. Recent years have seen much progress in the design of new linker activation strategies. Herein, we review the recent development of chemical strategies used to link the warhead with a delivery vehicle for preferential cleavage at the desired sites. K E Y W O R D S antibody-drug conjugates, click and release, drug delivery, linker chemistry, targeted delivery, triggered release 1 | INTRODUCTION In the world of drug discovery and development, the concept of "smart drugs" broadly refers to those that can selectively affect disease-relevant target(s). However, to a certain degree, essentially all drugs are already selective toward the desired target(s) whether they are enzyme inhibitors, receptor ligands, ion channel blockers, inhibitors of protein-protein interaction, or even genotoxins used for cancer chemotherapy, among others. They would not have made through the various milestones of drug discovery and developmental processes if they were not sufficiently selective for the intended target(s). However, once administered into the human body, the highly complex living system often leads to many unexpected off-target effects. Thus, various additional approaches have been studied and

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“…The combination of 1 O 2 -responsive nanocarriers with other treatment, such as photodynamic therapy (PDT), has remarkable synergistic therapeutic effects (Wang et al, 2016 ; Yang et al, 2016 ; Yu et al, 2016 ; Li et al, 2017b ; Liu et al, 2017a ). In PDT, non-toxic photosensitizers are activated by exogenous light of a specific wavelength to transfer their excited energy to the surrounding oxygen to produce ROS.…”

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 99%

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu

Chen

et al. 2020

Front. Chem.

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Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.

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A Reactive 1O2 - Responsive Combined Treatment System of Photodynamic and Chemotherapy for Cancer

Cited by 35 publications

References 52 publications

Functional Polymer Nanocarriers for Photodynamic Therapy

Functional Polymer Nanocarriers for Photodynamic Therapy

Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

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