2020
DOI: 10.1039/d0bm01660h
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A reactive oxygen species-responsive antioxidant nanotherapy for the treatment of drug-induced tissue and organ injury

Abstract: An antioxidant nanotherapy engineered from a reactive oxygen species (ROS)-responsive and ROS-eliminating cyclodextrin material can be used for the treatment of drug-induced gastrointestinal and liver injury.

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Cited by 13 publications
(6 citation statements)
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“…Degradation of Hydrogels and Drug Release Analysis: Hydrogels of 5 mm diameter and 5 mm length were used, and the same three samples were evaluated in each group. Samples were immersed in PBS (1 mL) with MMP-9 (20 × 10 −9 m), [44] glucose (5 × 10 −3 m as normal glucose or 25 × 10 −3 m as high glucose), [45] or H 2 O 2 (1 × 10 −3 m) [46] at room temperature. Moreover, the hydrogels were immersed in diabetic-mimicking solution (PBS containing MMP-9 [20 × 10 −9 m], H 2 O 2 [1 × 10 −3 m], and glucose [25 × 10 −3 m]) to test the cumulative degradation with the three cues coexisting.…”
Section: Methodsmentioning
confidence: 99%
“…Degradation of Hydrogels and Drug Release Analysis: Hydrogels of 5 mm diameter and 5 mm length were used, and the same three samples were evaluated in each group. Samples were immersed in PBS (1 mL) with MMP-9 (20 × 10 −9 m), [44] glucose (5 × 10 −3 m as normal glucose or 25 × 10 −3 m as high glucose), [45] or H 2 O 2 (1 × 10 −3 m) [46] at room temperature. Moreover, the hydrogels were immersed in diabetic-mimicking solution (PBS containing MMP-9 [20 × 10 −9 m], H 2 O 2 [1 × 10 −3 m], and glucose [25 × 10 −3 m]) to test the cumulative degradation with the three cues coexisting.…”
Section: Methodsmentioning
confidence: 99%
“…[ 205 ] Our previous studies showed that a multifunctional antioxidant nanomedicine (TON), based on a CD‐derived ROS‐sensitive material and Tpl, was able to scavenge a broad spectrum of ROS. [ 206 ] After oral administration, TON could accumulate at the inflamed site in a mouse model of GI injury induced with indomethacin (IND). In addition, oral treatment with TON efficaciously alleviated IND‐induced gastric and intestinal injury in mice, by effectively suppressing local oxidative and inflammatory responses.…”
Section: Therapeutic Applications Of Bioactive CD Material‐derived Na...mentioning
confidence: 99%
“…12 A). The loaded small-molecule antioxidants can be divided into three categories: natural antioxidants (such as curcumin [ [221] , [222] , [223] , [224] , [225] ], silymarin [ [226] , [227] , [228] , [229] ], resveratrol [ 230 ], carvacrol [ 231 ], polydatin [ 232 ], carnosic acid [ 233 ], quercetin [ 234 , 235 ], and other compounds [ 231 , [236] , [237] , [238] , [239] , [240] , [241] , [242] , [243] , [244] , [245] , [246] , [247] , [248] , [249] , [250] , [251] , [252] ]), synthetic antioxidants (nitroxide 4-amino-2,2,6,6-tetramethylpiperidine-N-oxyl, tempol [ [253] , [254] , [255] , [256] , [257] , [258] ]), and human endogenous antioxidants (melatonin [ 259 , 260 ], bilirubin [ 261 ], ubiquinone (CoQ10) [ 262 ], and carbon monoxide (CO) [ 263 ]) ( Fig. 12 B–C).…”
Section: Nanocarriers Of Small-molecule Antioxidantsmentioning
confidence: 99%