Abstract. This paper deals with the Vehicle Routing Problem with Simultaneous Pick-up and Delivery and Time Limit (VRPSPDTL). Due to the combinatorial nature of the problem, heuristics methods are commonly used to generate good quality solutions within an acceptable computational time. Accordingly, an Iterated Local Search (ILS) procedure that uses a Variable Neighborhood Descent (VND) method to perform the local search is proposed. The algorithm was applied to test problems and, in most cases, was found to produce better results than those reported in the literature.