A reagentless non-enzymatic hydrogen peroxide sensor presented using electrochemically reduced graphene oxide modified glassy carbon electrode

Mutyala, Sankararao; Mathiyarasu, J.

doi:10.1016/j.msec.2016.06.069

Cited by 70 publications

(41 citation statements)

References 65 publications

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“…Numerous comprehensive and critical reviews have highlighted the impact of graphene in electrochemistry in general, particularly for H 2 O 2 determination. 30,[281][282][283][284][285][286][287][288] Glassy carbon electrodes have been modified with graphene or graphene oxide 289,290 resulting in a detection limit for [H 2 O 2 ] of 50-700 nM.…”

Section: G87mentioning

confidence: 99%

Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy

Gulaboski

Mirčeski

Kappl

et al. 2019

J. Electrochem. Soc.

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Reactive oxygen species (ROS) exhibit different spatial and temporal distributions as well as concentrations in-and outside the cell, thereby functioning as signaling or pathogen-destroying molecules. Especially the ROS H 2 O 2 is important for the patho/physiological status of an organism. Electrochemistry (EM) and electron spin resonance (ESR)-based techniques allow quantification of H 2 O 2 in artificial and living systems, coping a concentration range from low nM up to mM. Working electrodes for EM are optimized by diverse modifications and, additionally, redox mediators are used. Ultramicroelectrodes allow scanning of single cells to spatially resolve and quantify extracellular H 2 O 2 in real-time. With ESR spectroscopy, • O 2¯, but not H 2 O 2 , can be directly determined by spin probes in-and outside of cells in suspensions. Monitoring H 2 O 2 requires formation of intermediate radicals, detectable with spin probes. Low μM [H 2 O 2 ] can thus be assessed specifically. Using suitable spin traps, in-vivo ESR and immuno-spin trapping can visualize different radicals at their respective production sites in small animals, organs and tissues. Here, the redox reaction cascades may interfere with cell metabolism. Optimization of all methods established for H 2 O 2 determination would be favorable to finally combine them for mutual validation. Thus, a deeper insight into cellular ROS metabolism can be obtained.

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Section: G87mentioning

confidence: 99%

Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy

Gulaboski

Mirčeski

Kappl

et al. 2019

J. Electrochem. Soc.

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“…To overcome these issues and further modulate the rate of transformation by using electrochemical methods for biosensing are proposed in the literature . Among them, non‐enzymatic electrochemical biosensing demonstrates the high selectivity, sensitivity, and also having low cost effective compared to other existing enzymatic and even non‐enzymatic methods …”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] Among them, non-enzymatic electrochemical biosensing demonstrates the high selectivity, sensitivity, and also having low cost effective compared to other existing enzymatic and even non-enzymatic methods. [21][22][23][24][25] In view of this, biosensing of H 2 O 2 by using nonenzymatic electrochemical system have explored considerable attention because of its significant role in a variety of enzymatic biotransformations in human body especially it acts as an oxidizing agent. [26] Therefore, it is meaningful to search a facile and efficient method to synthesize the functionalized graphene based nanoelectrodes having high selectivity, sensitivity, durability with lower overall cost for nonenzymatic H 2 O 2 detection.…”

Section: Introductionmentioning

confidence: 99%

Tyramine Functionalized Graphene: Metal‐Free Electrochemical Non‐Enzymatic Biosensing of Hydrogen Peroxide

et al. 2018

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We report here non‐enzymatic electrochemical biosensing of H2O2 using a highly stable, metal‐free, tyramine functionalized graphene (T‐GO) based electrocatalytic system. The surface functionalization of tyramine on graphene was carried out chemically. The obtained sheets were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD) as well as X‐ray photoelectron (XP), Raman, FT‐IR and UV‐visible spectroscopy. More significantly, the combined results from morphological and structural studies show the formation of a few layers of graphene with effective large‐scale functionalization by tyramine. As a metal‐free electrocatalyst, the as‐synthesized T‐GO shown good electrocatalytic activity towards reduction of H2O2 with a sensitivity of 0.105 mM/cm2 confirmed by combined results from cyclic voltammetric (CV) and linear sweep voltammetric (LSV), and amperometric (i–t) measurements. The lower onset potential (−0.23 mV vs SCE), lower detection limit, wider concentration range (10 mM to 60 mM) with higher electrochemical current and potential stability demonstrated the potential of our non‐enzymatic and cost‐effective T‐GO based electrocatalytic system towards reduction of hydrogen peroxide.

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“…According to them, the adsorption of H atom is better on the electrode devoid of the functional groups mentioned above. Mutyala et al . have reported electrochemical reduction of oxygenated species at graphene oxide surface upon subjecting to negative potential.…”

Section: Introductionmentioning

confidence: 99%

On In–situ Redox Balancing of Vanadium Redox Flow Battery Using D‐Fructose as Negative Electrolyte Additive

Pasala

Ramanujam

2017

ChemistrySelect

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Vanadium redox flow battery (VRFB) is an energy storage system, wherein V2+/V3+ and VO2+/VO2+ are used as negative and positive electrolyte respectively. It is well known that, V2+/V3+ redox reaction is sluggish in comparison to that of VO2+/VO2+ reaction. As the redox potential of V2+/V3+ redox‐couple is more negative to that of H+/H2 redox‐couple, during the V2+ formation hydrogen evolution occurs concomitantly, which affects the capacity retention of VRFB inducing redox couples concentration imbalance between the positive and negative electrolytes. In this study, we have explored the beneficial effect of D‐fructose as an additive to the negative electrolyte. D‐fructose (i) enhances the interfacial area of the graphite felt negative electrode‐electrolyte interface by wetting, thereby the current due to V2+/V3+ redox reaction at a given overpotential, (ii) suppresses the H2 evolution at negative electrode during charging of VRFB (iii) controls the VO2+ accumulation at the positive electrolyte and (iv) chemically reduces the VO2+ arriving at negative electrode side through crossover, thereby avoiding the direct reaction between V2+ and VO2+. A capacity retention of 86 % and 25 % is achieved at the end of the 25th cycle in the presence and absence of D‐fructose in the negative electrolyte, respectively. This way of in‐situ redox balancing alleviates the requirement for external redox balancing of the electrolyte, and help VRFB to deliver constant capacity with cycles.

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A reagentless non-enzymatic hydrogen peroxide sensor presented using electrochemically reduced graphene oxide modified glassy carbon electrode

Cited by 70 publications

References 65 publications

Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy

Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy

Tyramine Functionalized Graphene: Metal‐Free Electrochemical Non‐Enzymatic Biosensing of Hydrogen Peroxide

On In–situ Redox Balancing of Vanadium Redox Flow Battery Using D‐Fructose as Negative Electrolyte Additive

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