A Reappraisal of Eosinophilic Granuloma of Bone, Hand-Sghüller-Christian Syndrome and Letterer-Siwe Syndrome

Histiocytosis X in an Adult with Skin and Uncommon Central Nervous System Involvement

“…The age of onset and the CNS involvement which normally is considered to be typi cal for the Hand-Schiiller-Christian type [ 10] are unusual features of our case.…”

“…Reviewing the literature about histiocytosis X one can see that the main difference between the three clinical types: Letterer-Siwe disease, HandSchiiller-Christian disease and eosinophilic granuloma, lies in the course and in the prognosis of the disease [10].…”

A case of histiocytosis X associated with panhypopituitarism and hyperimmunoglobulinemia G and E.

“…The patient described here had the classical triad of Hand-Schueller-Christian disease and may be also diagnosed as histiocytosis X according to Lichtenstein (1953) or as multifocal eosinophilic granuloma according to Lieberman et al(1969). But at present proper classification of these abnormal proliferations of histiocytes remains unsolved.…”

Multifocal Eosinophilic Granuloma

“…In spite of their pathologic similarities, these dis orders are quite heterogeneous in their sites of involvement, age of onset, morbid ity, and mortality. This clinical heterogenity has led to disagreement over the classi fication of the histiocytic disorders [6,9]. Classic unifocal eosinophilic granu loma involves isolated organs such as lung or bone.…”