A reasoned approach towards administering COVID‐19 vaccines to pregnant women

COVID-19 is a pandemic of the 21st century that recorded 234 809 103 confirmed cases and more than 4 800 375 deaths. Many studies report the effect of COVID-19 in the overall population; nevertheless, there is information scarceness related to pharmacological management and pregnancy and fetal outcomes during the epidemic. Pregnancy is a state of change in immune physiology and anatomy modulation in preference to immune suppression. Additionally, manifold interactions with the health care system during pregnancy increases the chance of infection, and managing, pregnant population poses a more significant challenge. This review will summarize the available data on pharmacological considerations and vaccines in pregnancy and their adverse effects on fetal outcomes. Several drug choices include but are not limited to antivirals and antimalarial and combinations, corticosteroids, nonsteroidal anti-inflammatory drugs, and antipyretics. Approved vaccines for pregnancy include Pfizer/BioNTech and mRNA-1273 Moderna/National Institutes of Health. COVID-19 treatment approaches vary across different countries; the WHO and the Centers for Disease Control and Prevention guidelines and country regulators advise managing adverse effects on pregnancy and fetal outcome. But the efficacy of these drugs is questionable. There is no adequate literature to demonstrate the safety of these drugs in pregnant and lactating women. Hence, well-conducted studies that assess the safety of anti-COVID-19 medications and vaccines in pregnancy and lactating women are needed.

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“…In February 2021, the Pfizer/BioNTech vaccine was the first trial in pregnant women (ClinicalTrials.gov identifier: NCT04754594). 16…”

Section: Covid-19 In Pregnancymentioning

confidence: 99%

Pharmacological consideration of COVID-19 infection and vaccines in pregnancy

Mohapatra¹,

A²,

Tripathy³

2022

Journal of the Chinese Medical Association

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“…To cite this article: Salem, F. E.; Ali, S. M.; Aboulwafa, M. M.; Shawky, R. M. COVID- 19 4 . Table 1 illustrates the properties of the five most commonly used vaccines that have received EUA.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccination During Gestation and Lactation: Leaps in Comprehension

Fatma

Mahmoud

et al. 2022

Journal of Advanced Pharmacy Research

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“…Although the second year of the pandemic has been characterized by a better understanding of COVID-19, the production of effective vaccines, 21 a larger armamentarium of treatment options, 22 , 23 and better PPE availability, it has also seen the emergence of more transmissible variants of concern such as the delta 24 , 25 and omicron variants, 26 , 27 which has increased uncertainty. Several countries, such as Singapore, are increasingly transiting from a zero-COVID policy to one that accepts COVID-19 endemicity.…”

mentioning

confidence: 99%