A Recent Update on Drug Delivery Systems for Pain Management

Phadke, Apoorva; Amin, Purnima D.

doi:10.1080/15360288.2021.1925386

Cited by 7 publications

(2 citation statements)

References 301 publications

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“…Such discomfort can also occur without any physical derangement, as stated in the definition proposed by the International Association for the Study of Pain (IASP). 28 Despite significant advances in pain management, it remains a challenging burden both for the patients and their doctors. The most pain-affected group of patients comprises cancer patients, who suffer from pain chronically.…”

Section: What Do We Know About Clinically Important Cannabinoids?mentioning

confidence: 99%

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

Sobieraj,

Strzelecka,

Sobczak

et al. 2024

IJN

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Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms and inflammatory reactions of the organism, thus inevitably affecting maintenance of homeostasis. Medical Cannabis popularity has surged since its legal regulation growing around the world. Numerous promising discoveries bring more data on cannabinoids’ pharmacological characteristics and therapeutic applications. Given the current surge in interest in the medical use of cannabinoids, there is an urgent need for an effective method of their administration. Surpassing low bioavailability, low water solubility, and instability became an important milestone in the advancement of cannabinoids in pharmaceutical applications. The numerous uses of cannabinoids in clinical practice remain restricted by limited administration alternatives, but there is hope when biodegradable polymers are taken into account. The primary objective of this review is to highlight the wide range of indications for which cannabinoids may be used, as well as the polymeric carriers that enhance their effectiveness. The current review described a wide range of therapeutic applications of cannabinoids, including pain management, neurological and sleep disorders, anxiety, and cancer treatment. The use of these compounds was further examined in the area of dermatology and cosmetology. Finally, with the use of biodegradable polymer-based drug delivery systems (DDSs), it was demonstrated that cannabinoids can be delivered specifically to the intended site while also improving the drug’s physicochemical properties, emphasizing their utility. Nevertheless, additional clinical trials on novel cannabinoids’ formulations are required, as their full spectrum therapeutical potential is yet to be unravelled.

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Section: What Do We Know About Clinically Important Cannabinoids?mentioning

confidence: 99%

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

Sobieraj,

Strzelecka,

Sobczak

et al. 2024

IJN

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“…Achieving optimal bioavailability and maintaining steady-state concentrations of phytocompounds in conventional formulations pose significant challenges in their conversion into therapeutic agents. However, parenteral preparations with 100% bioavailability have limitations such as drug release control and targeting the specific site of action or receptor (12). Despite the potential pharmacological activities of guggulsterone, its low bioavailability and water insolubility hinder its conversion into an effective therapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Guggulsterone phytosomes: A novel approach to alleviate hyperlipidemia in high-fat diet-fed rats

Dudekula,

Koilpillai,

Narayanasamy

2024

J Herbmed Pharmacol

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Introduction: Guggulsterone, derived from Commiphora mukul, is a potent hypolipidemic medication with low bioavailability and water insolubility. To address these challenges, the study aimed to formulate phytosomes and evaluate the efficacy of guggulsterone phytosomes (GPs) in reducing hyperlipidemia in rats on a high-fat diet. Methods: GPs were formulated by incorporating soya lecithin with a suitable solvent to enhance their efficacy against hyperlipidemia induced by a high-fat diet in rats. The optimized GPs were characterized, and in vitro drug release pattern was examined. The hypolipidemic effect of GPs (25 mg/kg body weight) was evaluated in Sprague Dawley rats over 28 days. Results: The GPs demonstrated favorable entrapment effectiveness with a particle size of 145.4 nm and a zeta potential of -17.8 mV. In terms of drug release, the GPs exhibited better stability and bioavailability, with a release of 92.07 ± 1.67% within 24 hours, compared to pure guggulsterone, which only released 28.07 ± 0.81%. GPs elevated the levels of high-density lipoprotein (HDL) and significantly (P<0.05) reduced triglycerides (TG), low-density lipoprotein (LDL) levels, and total cholesterol (TC), compared to their respective control groups. Moreover, GPs showed substantial (P<0.05) antioxidant activity, reduced steatosis, inflammatory cell, and fat cell infiltration in the liver tissue. Conclusion: GPs exhibited hypolipidemic activity in rats with high-fat diet-induced hyperlipidemia compared to pure guggulsterone. These findings emphasize the potential of GPs as an effective therapeutic intervention for managing hyperlipidemia, surpassing the conventional use of the pure compound.

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Orally Disintegrating Film of High-Dose BCS II Drug by Hot Melt Extrusion through Design of Experiment

Phadke

Amin

2022

J Pharm Innov

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A Recent Update on Drug Delivery Systems for Pain Management

Cited by 7 publications

References 301 publications

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

Guggulsterone phytosomes: A novel approach to alleviate hyperlipidemia in high-fat diet-fed rats

Orally Disintegrating Film of High-Dose BCS II Drug by Hot Melt Extrusion through Design of Experiment

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