A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle, and cancer

Assoian, Richard K.; Yung, Yuval

doi:10.4161/cc.7.1.5232

Cited by 40 publications

(32 citation statements)

References 35 publications

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“…The dysfunction of cyclin D-CDK4/6 and the coordinate alterations in cyclins, CDKs, and CKIs, which all point toward CDK2 activation, strongly suggest that GPC1 may inactivate pRb by a cyclin D-CDK4/6-independent mechanism, namely the Skp2 autoinduction loop (23). It represents a positive feedback loop within the pRb-E2F regulation network, comprised of pRb-E2F, Skp2, p27/p21, and cyclin E/A-CDK2.…”

Section: Gpc1mentioning

confidence: 99%

Glypican-1 Stimulates Skp2 Autoinduction Loop and G1/S Transition in Endothelial Cells

Qiao¹,

Meyer²,

Friedl³

2012

Journal of Biological Chemistry

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Background: Glypican-1 is a cell surface heparan sulfate proteoglycan that regulates cell growth. Results: In endothelial cells, glypican-1 regulates a variety of cell cycle effectors leading to increased S phase entry. Conclusion: Glypican-1 inactivates the G 1 /S checkpoint, apparently by activating the Skp2 autoinduction loop. Significance: These findings provide mechanistic insights into how glypican-1 regulates the cell cycle and proliferation.

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Section: Gpc1mentioning

confidence: 99%

Glypican-1 Stimulates Skp2 Autoinduction Loop and G1/S Transition in Endothelial Cells

Qiao¹,

Meyer²,

Friedl³

2012

Journal of Biological Chemistry

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“…Homozygous deletion appears to be the major mechanism affecting CDKN2A-ARF, whereas inactivating mutations coupled with allelic loss occur at the NF2 locus [78]. Mesothelioma, as opposed to most other cancers, rarely has mutated TP53, but loss of p14 ARF indirectly inactivates p53 [79]. Restoring p14…”

Section: Figurementioning

confidence: 99%

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

2015

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Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society. @ERSpublications Malignant pleural mesothelioma is a cancer with increasing death tolls due to the past and present use of asbestos http://ow.ly/DhA2y

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“…Cyclic-AMP response element binding protein (CREB), 36 E2F, [37][38][39] NFκB (via Iκ-K), 40,41 and the forkhead transcription factors [42][43][44][45][46][47][48][49][50] are all either direct or indirect substrates of Akt and each can promote either cellular proliferation or survival. Aside from transcription factors, Akt is able to target a number of other molecules to affect the survival state of the cell including caspase-9, 51 the pro-apoptotic molecule BAD, 52,53 and glycogen-synthase kinase-3β (GSK-3β).…”

Section: Central Role Of Pi3k/pten/akt/mtor Pathway In Prostate Cancermentioning

confidence: 99%

Targeting prostate cancer based on signal transduction and cell cycle pathways

Lee¹,

Lehmann²,

Terrian³

et al. 2008

Cell Cycle

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A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle, and cancer

Cited by 40 publications

References 35 publications

Glypican-1 Stimulates Skp2 Autoinduction Loop and G1/S Transition in Endothelial Cells

Glypican-1 Stimulates Skp2 Autoinduction Loop and G1/S Transition in Endothelial Cells

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

Targeting prostate cancer based on signal transduction and cell cycle pathways

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