A recombinant trivalent vaccine candidate against human adenovirus types 3, 7, and 55

Liu, Tiantian; Zhou, Zhichao; Tian, Xingui; Liu, Wenkuan; Xu, Duo; Fan, Ye; Liao, Jiayi; Gu, Shujun; Li, Xiao; Zhou, Rong

doi:10.1016/j.vaccine.2018.02.050

Cited by 30 publications

(18 citation statements)

References 47 publications

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“…Because HAdV outbreaks are more prominent among trainees and low-rank soldiers recently discharged from training centers [20,21,34], such measures have been emphasized in training centers for new recruits [24]. Although an oral vaccine for HAdV-4 and -7 successfully controlled HAdV-ARI outbreaks in the United States military [35], it has not been adopted in the Korean military because HAdV-ARI is known to exhibit type-specific immunity, and HAdV-55 shares immunogenicity with HAdV-14 [9,36,37]. Several multi-valent HAdV vaccines targeting HAdV-55 are currently under development, but clinical application of these vaccines will take time [36,38].…”

Section: Discussionmentioning

confidence: 99%

“…Although an oral vaccine for HAdV-4 and -7 successfully controlled HAdV-ARI outbreaks in the United States military [35], it has not been adopted in the Korean military because HAdV-ARI is known to exhibit type-specific immunity, and HAdV-55 shares immunogenicity with HAdV-14 [9,36,37]. Several multi-valent HAdV vaccines targeting HAdV-55 are currently under development, but clinical application of these vaccines will take time [36,38]. More resources should be focused on vaccine development, and HAdV molecular typing must be implemented in surveillance systems for proper selection of HAdV vaccines in the future.…”

Section: Discussionmentioning

confidence: 99%

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Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Woo

et al. 2021

Korean J Intern Med

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0000-0002-7464-9780 *These authors contributed equally to this work. Background/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter. Methods: To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) results, pneumonia surveillance results, and severe HAdV cases from all 14 Korean military hospitals from January 2013 to May 2018 and compared these data with nationwide RV surveillance data for the civilian population. Results: A total of 14,630 RV-PCRs was performed at military hospitals. HAdV (45.4%) was the most frequently detected RV, followed by human rhinovirus (12.3%) and influenza virus (6.3%). The percentage of the military positive for HAdV was significantly greater than the percentage of civilians positive for HAdV throughout the study period, with a large outbreak occurring during the winter to spring of 2014 to 2015. The outbreak continued until the end of the study, and non-seasonal detections increased over time. The reported number of pneumonia patients also increased during the outbreak. Case fatality rate was 0.075% overall but 15.6% in patients with respiratory failure. The proportion of severe patients did not change significantly during the study period. Conclusions: A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Woo

et al. 2021

Korean J Intern Med

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“…Thus, HAdV‐B55 avoids herd immunity to HAdV‐B14, while retaining its respiratory pathogenicity . Recently isolated and genome‐characterized in China, HAdV‐B55 causes severe acute respiratory disease in immunocompetent adults worldwide , and of sufficient severity to warrant efforts to include it in a vaccine against other fatal respiratory adenoviruses, HAdV‐B3 and B7 . In contrast to marked hypervariability within HVRs of the HAdV‐D penton base gene and the entire fiber gene (see below), nucleotide diversity in the HAdV‐D hexon gene HVRs is comparatively less in HAdV‐Ds as compared to the other HAdV species .…”

Section: Human Adenovirus Species‐ and Type‐specific Features And Genmentioning

confidence: 99%

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

et al. 2019

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Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.

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“…HAdV-5 was cultured in AD293 cells, purified and stored at −80°C. The 50% tissue culture infective dose of the virus was determined following the routine procedure, as previously described [17].…”

Section: Virusesmentioning

confidence: 99%

Evaluation of an Innovative Pediatric Isolation Bed Using Fluid Dynamics Simulation and Physical Pollutants

Liu¹,

Guo²,

Hao³

et al. 2019

Preprint

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Background: Airborne transmission is an important mechanism of spread for both viruses and bacteria in hospitals, with nosocomial infections putting a great burden on public health. Patients in intensive care units are highly susceptible and these units by necessity already have incur high operating costs. Therefore, there is an urgent need for an economical medical device to prevent nosocomial infections. In order to achieve this goal, an innovative pediatric isolation bed was developed. Methods: We investigated the position of the child and air intake wind speed to test the local isolation effect of the bed using computational fluid dynamics simulation technology. Following this, we conducted purification experiments using cigarette smoke, and sustained release Staphylococcus albus and human adenovirus type 5 to demonstrate the isolation efficacy.Results: The results showed that the patient’s head should be placed as close to the air inlet hood as possible, and the value of air intake wind speed of 0.86 m/s was effective. The isolation efficacy of this innovative pediatric isolation bed is demonstrated by CFD technology and experiments using cigarette smoke and different kinds of microorganisms.Conclusions: The pediatric isolation bed is mobile and economic, particularly useful for where infectious isolation wards are unavailable, such as in intensive care units and primary clinical settings, to control hospital acquired infection. This study provides a new method for the prevention and control of nosocomial infections.

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A recombinant trivalent vaccine candidate against human adenovirus types 3, 7, and 55

Cited by 30 publications

References 47 publications

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

Evaluation of an Innovative Pediatric Isolation Bed Using Fluid Dynamics Simulation and Physical Pollutants

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