A reconstructed genome‐scale metabolic model of Helicobacter pylori for predicting putative drug targets in clarithromycin and rifampicin resistance conditions
Sepideh Mofidifar,
Abbas Yadegar,
Mohammad Hossein Karimi‐Jafari
Abstract:BackgroundHelicobacter pylori is considered a true human pathogen for which rising drug resistance constitutes a drastic concern globally. The present study aimed to reconstruct a genome‐scale metabolic model (GSMM) to decipher the metabolic capability of H. pylori strains in response to clarithromycin and rifampicin along with identification of novel drug targets.Materials and MethodsThe iIT341 model of H. pylori was updated based on genome annotation data, and biochemical knowledge from literature and databa… Show more
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