A recovered avian myelocytomatosis virus that induces lymphomas in chickens: pathogenic properties and their molecular basis

Genomic instability during Myc-induced lymphomagenesis in the bursa of Fabricius

“…The principal change was the use of a modified LmycSN defective vector in which the v-myc gene was replaced by a c-myc gene obtained from an RCAS vector (Hughes et al, 1987), the promoter driving c-myc replaced by a promoter from the long terminal repeat (LTR) of the recovered avian myelocytomatosis virus HB1 (Enrietto et al, 1983) and the selectable neo gene replaced by a green fluorescence protein marker. We have found that this HB1-derived promoter is highly active in chicken bursal cells (data not shown).…”

Evidence that c-myc expression defines two genetically distinct forms of colorectal adenocarcinoma

“…The human c-myc proto-oncogene is the genomic homologue of the transforming sequences found in MC29, an avian retrovirus that can cause myelocytomatosis, carcinoma, sarcoma and lymphoma (Graf & Beug, 1978;Enrietto et al, 1983). Alterations in the structure or expression of c-myc have been associated with several forms of neoplasia including avian leukosis virus induced Bcell lymphoma, rodent plasmacytoma and human Burkitt's lymphoma, leukaemia, colon carcinoma and variant small cell lung cancer (Hayward et al, 1981;Payne et al, 1982;Shen-Ong et al, 1982;Taub et al, 1982;Collins & Groudine, 1982;DallaFavera et al, 1982;Crews et al, 1982;Little et al, 1983;Sumegi et al, 1983;Mushinski et al, 1983;Alitalo etal., 1983;Erisman etal., 1985;Rothbergetal., 1984).…”

Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation

“…Similar findings were obtained using the 1W41 REV-transformed B-cell line, which also showed background VEGF levels (data not shown). The E3 cell line was infected with a replicationcompetent HB1 retrovirus (Enrietto et al, 1983;Smith et al, 1985), which expresses a 108 kD gag-v-Myc fusion protein, as well as smaller proteolytic products ( Figure 5a). These E3 þ Myc cells produce high levels of VEGF, similar to that produced by DT40 cells (Figure 5b).…”