“…Larger PDA, lower birth weight and lower platelet count have been also reported as significant predictors of high failure of pharmacological treatment [17] Muscular constriction, after pharmacological treatment, produces a region of ischemic hypoxia in the middle of the ductus muscle media that initiates the process of permanent closure. A recurrent symptomatic PDA has been also described after the initial course of pharmacological treatment [18][19][20]. The male Italian newborn infant of the case report [2] was referred at the age of 2 days to the Cardiology Unit for a cardiovascular check-up (in the text: "in a 3-day-old newborn infant" must be comprehended as " in a 2-day-old newborn infant")and was mature.…”