A red algal cyclophilin has an effect on development and growth in Nicotiana tabacum

Cho, Eun Kyung; Kim, Mihyang

doi:10.1016/j.plaphy.2008.05.013

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…These studies, hence, highlight the crucial role of OsCYP20-2 in integrating plant growth and abiotic stress response. As observed in transgenic tobacco plants that constitutively expressed GjCYP-1, a cyclophilin gene from red alga Griffithsia japonica, the PPIase-induced stress tolerance might also be associated with adverse effects on growth and yield (Cho and Kim, 2008), thereby, necessitating the use of stress-inducible promoters.…”

Section: Implications Of Cyclophilins In Abiotic Stress Responsementioning

confidence: 99%

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

et al. 2020

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Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the peptide bond preceding a proline residue, essential for correct folding of the proteins. Compared to prokaryotes and other eukaryotes studied until now, the cyclophilin gene families in plants exhibit considerable expansion. With few exceptions, the role of the majority of these proteins in plants is still a matter of conjecture. However, recent studies suggest that cyclophilins are highly versatile proteins with multiple functionalities, and regulate a plethora of growth and development processes in plants, ranging from hormone signaling to the stress response. The present review discusses the implications of cyclophilins in different facets of cellular processes, particularly in the context of plants, and provides a glimpse into the molecular mechanisms by which these proteins fine-tune the diverse physiological pathways.

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Section: Implications Of Cyclophilins In Abiotic Stress Responsementioning

confidence: 99%

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

et al. 2020

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“…Transcript of GjCyp -1 is induced by plant hormones such as gibberellic acid (GA3), indoleacetic acid (IAA) and zeatin (ZA). Constitutive overexpression of GjCyp-1 appeared to be beneficial to seed germination 75 . Rice OsCyp2 gene has been shown to be induced by multiple abiotic stresses 63 , 64 …”

Section: Cyclophilins: Stress Dependent Regulation and Genetic Manipumentioning

confidence: 99%

“…The ratio of emergence of cotyledon from seeds overexpressing GjCyp-1 was almost three times higher than that of transgenic seeds carrying only the vector. In addition, it was found that seedlings overexpressing GjCyp -1 showed thermotolerance and transgenic plants were short statured with altered root system 75 . Overexpression of rice cyclophilin gene, OsCyp2 , has been shown to enhance multiple stress tolerance in E. coli and S. cerevisiae 63 .…”

Section: Cyclophilins: Stress Dependent Regulation and Genetic Manipumentioning

confidence: 99%

Cyclophilins: Proteins in search of function

Kumari

Roy

Singh

et al. 2013

Plant Signaling & Behavior

130

118

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Cyclophilins constitute a subgroup of large family of proteins called immunophilins, which also include FKBPs and Parvulins. They are remarkably conserved in all genera, highlighting their pivotal role in important cellular processes. Most cyclophilins display PPIase enzymatic activity, multiplicity, diverse cellular locations and active role in protein folding which render them to be included in the class of diverse set of proteins called molecular chaperones. Due to their distinct PPIase function, besides protein disulfide isomerases and protein foldases, cyclophilins have been deemed necessary for in vivo chaperoning activity. Unlike other cellular chaperones, these proteins are specific in their respective targets. Not all cyclophilin proteins possess PPIase activity, indicating a loss of their PPIase activity during the course of evolution and gain of function independent of their PPIase activity. The PPIase function of cyclophilins is also compensated by their functional homologs, like FKBPs. Multiple cyclophilin members in plants like Arabidopsis and rice have been reported to be associated with diverse functions and regulatory pathways through their foldase, scaffolding, chaperoning or other unknown activities. Although many functions of plant cyclophilins were reported or suggested, the physiological relevance and molecular basis of stress-responsive expression of plant cyclophilins is still largely unknown. However, their wide distribution and ubiquitous nature signifies their fundamental importance in plant survival. Several of these members have also been directly linked to multiple stresses. This review attempts to deal with plant cyclophilins with respect to their role in stress response.

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Expression of a cyclophilin OsCyp2-P isolated from a salt-tolerant landrace of rice in tobacco alleviates stress via ion homeostasis and limiting ROS accumulation

Kumari

Joshi

Singh

et al. 2014

Funct Integr Genomics

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Cyclophilins are a set of ubiquitous proteins present in all subcellular compartments, involved in a wide variety of cellular processes. Comparative bioinformatics analysis of the rice and Arabidopsis genomes led us to identify novel putative cyclophilin gene family members in both the genomes not reported previously. We grouped cyclophilin members with similar molecular weight and subtypes together in the phylogenetic tree which indicated their co-evolution in rice and Arabidopsis. We also characterized a rice cyclophilin gene, OsCyp2-P (Os02g0121300), isolated from a salinity-tolerant landrace, Pokkali. Publicly available massively parallel signature sequencing (MPSS) and microarray data, besides our quantitative real time PCR (qRT-PCR) data suggest that transcript abundance of OsCyp2-P is regulated under different stress conditions in a developmental and organ specific manner. Ectopic expression of OsCyp2-P imparted multiple abiotic stress tolerance to transgenic tobacco plants as evidenced by higher root length, shoot length, chlorophyll content, and K(+)/Na(+) ratio under stress conditions. Transgenic plants also showed reduced lipid peroxidase content, electrolyte leakage, and superoxide content under stress conditions suggesting better ion homeostasis than WT plants. Localization studies confirmed that OsCyp2-P is localized in both cytosol and nucleus, indicating its possible interaction with several other proteins. The overall results suggest the explicit role of OsCyp2-P in bestowing multiple abiotic stress tolerance at the whole plant level. OsCyp2-P operates via reactive oxygen species (ROS) scavenging and ion homeostasis and thus is a promising candidate gene for enhancing multiple abiotic stress tolerance in crop plants.

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A red algal cyclophilin has an effect on development and growth in Nicotiana tabacum

Cited by 4 publications

References 47 publications

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Cyclophilins: Proteins in search of function

Expression of a cyclophilin OsCyp2-P isolated from a salt-tolerant landrace of rice in tobacco alleviates stress via ion homeostasis and limiting ROS accumulation

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