A reduced calorie-high fiber diet retards age-associated decreases in muscarinic receptor sensitivity

Joseph, James A.; Algeri, S.; Decesare, A.; Comuzio, M.; Erat, S.; Kelly, Jeremiah F.; Cagnotto, Alfredo; Mennini, Tiziana

doi:10.1016/0197-4580(95)00073-n

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…With specific reference to the present findings, reasonable explanations can be inferred from previous papers reporting consistent changes in the lipid composition and physicochemical properties of the neuronal membrane of rats fed with the same reduced calorie-high fibre diet (13,36). Namely, it has been found that old food restricted rats show significant reductions in the cholesterol/phospholipid and in the sphingomyelin/phosphatidytcholine ratios suggesting that these modifications oppose the age-related decrease in the fluidity of brain membranes.…”

Section: Discussionsupporting

confidence: 88%

“…In conclusion, the present findings document that dietary restriction is capable of a positive modulation of the synaptic dynamic morphology which may be due to the many reported effects of a reduced caloric intake on free radical generation and/or control (4,6,7,(35)(36)(37)(38)(39)41).…”

Section: Discussionsupporting

confidence: 62%

“…Although the mechanism(s) by which a reduced caloric intake retards many age-related alterations is yet unknown (35)(36)(37)(38)(39), there is consensus proposing that dietary restriction triggers a multifactorial process responsible of a decreased cellular load of labile and damaged proteins, lipids and DNA (35). With specific reference to the present findings, reasonable explanations can be inferred from previous papers reporting consistent changes in the lipid composition and physicochemical properties of the neuronal membrane of rats fed with the same reduced calorie-high fibre diet (13,36).…”

Section: Discussionmentioning

confidence: 99%

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Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

Bertoni–Freddari

Fattoretti

Caselli

et al. 1999

AGE

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A computer-assisted morphometric study has been carried out on the synaptic ultrastructural features in the hippocampus of 14-month old (DR14) and 27-month old (DR27) dietary restricted (-50% lipids and -35% carbohydrates) rats. Age-matched controls were maintained on an ad libitum (AL) feeding schedule. Synaptic numeric density (Nv), surface density (Sv) and average area (S) were the parameters measured. In old AL vs. adult AL animals, Nv decreased to a not significant extent, while S increased and Sv decreased significantly. In DR14 rats vs. AL littermates Nv increased significantly, but S and Sv were unchanged. DR27 rats vs. agematched AL controls showed a significant increase of Nv and Sv while S was significantly decreased. Comparing DR14 vs. DR27, no significant difference due to age was documented. Both in DR14 and in DR27 groups the percent distribution of S showed a marked increase of smaller contact zones. Despite reporting on discrete aspects of synaptic ultrastructure, Nv and S are supported to be in an inverse relationship which aims at maintaining Sv constant. Thus, these three ultrastructural parameters when taken together per experimental group, appear to provide information on synaptic morphological rearrangements. In this context, the percent increase of smaller synapses in DR animals is consistent with the idea of a marked remodelling process. Considering previous data from the same groups of rats reporting significant changes in neuronal membrane lipid composition and fluidity, we interpret our findings to account for a positive modulation of dietary restriction on the synaptic structural dynamics.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

Bertoni–Freddari

Fattoretti

Caselli

et al. 1999

AGE

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The membrane hypothesis of aging: its relevance to recent progress in genetic research

Zs-Nagy

1997

J Mol Med

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This review outlines the main concepts of the membrane hypothesis of aging (MHA) developed over the past two decades. MHA offers a general cell biological mechanism to explain the main trends of age-dependent changes in terms of intracellular physicochemistry. An essential point in MHA is that the inevitable plasma membrane alterations result in the accumulation of dry mass in the intracellular space, a process that is essential to cellular development and organismal maturation, but which becomes a rate limiting factor above a certain physical density of the cell colloids. The main statements of the MHA are supported by recent developments in molecular genetics. Specifically, the great majority of the products of oncogenes and antioncogenes are localized to the plasma membrane, indicating a central role of the plasma membrane in mitotic regulation, cell differentiation and senescence.

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Growth Hormone, Insulin-like Growth Factor- 1, and the Aging Brain

Thornton¹,

Sonntag²

2001

Functional Neurobiology of Aging

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A reduced calorie-high fiber diet retards age-associated decreases in muscarinic receptor sensitivity

Cited by 6 publications

References 55 publications

Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

The membrane hypothesis of aging: its relevance to recent progress in genetic research

Growth Hormone, Insulin-like Growth Factor- 1, and the Aging Brain

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