A reduced-order model for deformable particles with application in bio-microfluidics

Nair, Achuth Nair Balachandran; Pirker, Stefan; Umundum, Thomas; Saeedipour, Mahdi

doi:10.1007/s40571-019-00283-8

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…Despite the accuracy of current blood flow models, simulating complex conditions remains challenging because of the high computational load and cost. Balachandran Nair et al 57 suggested a reduced order model of RBC under the framework of DEM, where the RBC is represented by overlapping constituent rigid spheres. The Morse potential force is adapted to account for the RBC aggregation exhibited by cell to cell interactions among RBCs at different distances.…”

Section: Numerical Methods (Fdm Fem Fvm)mentioning

confidence: 99%

Review on Blood Flow Dynamics in Lab-on-a-Chip Systems: An Engineering Perspective

Lai,

Zhu,

Chen

et al. 2024

Chem Bio Eng.

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Under different transport mechanisms, blood flow dynamics, heavily linked to the flow shear rate conditions, in "labon-a-chip" (LOC) systems are found to result in varying transport phenomena. This Review examines the blood flow patterns in LOC systems through the role of viscoelastic properties such as dynamic blood viscosity and elastic behavior of the red blood cells. The study of blood transport phenomena in LOC systems through key parameters of capillary and electro-osmotic forces is provided through experimental, theoretical, and numerous numerical approaches. The disturbance triggered by electro-osmotic viscoelastic flow is particularly discussed and applied in the enhancement of the mixing and separating capabilities of LOC devices handling blood and other viscoelastic fluids for future research opportunities. Furthermore, the Review identifies the challenges in the numerical modeling of blood flow dynamics under the LOC systems, such as the call for more accurate and simplified blood flow models and the emphasis on numerical studies of viscoelastic fluid flow under the electrokinetic effect. More practical assumptions for zeta potential conditions while studying the electrokinetic phenomena are also highlighted. This Review aims to provide a comprehensive and interdisciplinary perspective on blood flow dynamics in microfluidic systems driven by capillary and electro-osmotic forces.

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Section: Numerical Methods (Fdm Fem Fvm)mentioning

confidence: 99%

Review on Blood Flow Dynamics in Lab-on-a-Chip Systems: An Engineering Perspective

Lai,

Zhu,

Chen

et al. 2024

Chem Bio Eng.

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“…Similarly, an air-cavity-based syringe system has been used to study the variations in blood flow velocities and the image intensities of clogged RBCs [171]. Mathematical models of deformable RBC with Discrete Element Methods have also been taken into account, along with the lattice Boltzmann models of immersed boundaries [172,173]. Other relevant studies include the assessment of shear dependencies in RBC adhesion [174], analysis of the changes in RBC stiffness [175], mechanical characterization of stored RBCs via mathematical models [176], donor-dependent aging curves based on microfluidic RBC models [177], effects of channel geometry in RBC sorting [178], and the assessment of RBC deformity using iron-dextran tests [179].…”

Section: Deformation Of Single Erythrocytes In Microchannelsmentioning

confidence: 99%

Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

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The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.

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“…flexible bond models in CFD-DEM simulations. 5,6 It is assumed, that elastic solid beads could also serve as good models for biological particles. 7 Additionally, such soft particle models are of particular interest in the field of microfluids, like transportation of soft particles through rectangular micro ducts.…”

Section: Introductionmentioning

confidence: 99%