Selenium deficiency in crops has become a subject of growing concern where soil Se concentration is low. The mechanisms of Se translocation in the soil-rice system is very complex and the influence of heavy metal elements and nutrient concentrations on Se translocation in the soil-rice system is unknown. Our study investigated concentrations of Se, heavy metals like Hg, Cd, and Pb, and nutrient elements like Ca, K, P, and S in soils and rice tissues (roots, stems, and grains) in different industrial regions in Jiangsu Province, China. The transfer of Se in the soil-rice system was calculated by transfer coefficients (TC Se ) in this study. The results showed that Se transfer from soil to roots and from stems to grain were key steps for controlled Se concentration in rice grains. The multiple linear regression analysis makes an implication that some elements influence the Se transfer significantly: soil K and Hg may suppress Se entering rice roots; B, Cu, and Mo in rice root may restrain Se transfer from root to stem; and S, Cr, P, and Mg in rice stem had negative effects on Se accumulation in rice grain. Therefore, reducing heavy metal pollution and managing fertilizer amounts may elevate Se concentration in rice grain, especially when Se concentration in soils is low.