2020
DOI: 10.1111/papr.12922
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A Regions of Interest Voxel‐Based Morphometry Study of the Human Brain During High‐Frequency Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome

Abstract: Introduction: The effectiveness of spinal cord stimulation (SCS) as pain-relieving treatment for failed back surgery syndrome (FBSS) has already been demonstrated. However, potential structural and functional brain alterations resulting from subsensory SCS are less clear. The aim of this study was to test structural volumetric changes in a priori chosen regions of interest related to chronic pain after 1 month and 3 months of high-frequency SCS in patients with FBSS. Methods: Eleven patients with FBSS who were… Show more

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Cited by 11 publications
(15 citation statements)
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References 65 publications
(137 reference statements)
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“… 41 Authors of the fMRI study followed-up with another study to test structural volumetric changes in chosen regions of interest of brain in patients with 10 kHz SCS implants and documented significant decreases in left and right hippocampus volume over time, which correlated with reduction in back pain intensity. 42 Taken together, the findings demonstrate 10 kHz SCS treatment is associated with unique objective physiological responses and sustained pain relief.…”
Section: Discussionmentioning
confidence: 76%
See 1 more Smart Citation
“… 41 Authors of the fMRI study followed-up with another study to test structural volumetric changes in chosen regions of interest of brain in patients with 10 kHz SCS implants and documented significant decreases in left and right hippocampus volume over time, which correlated with reduction in back pain intensity. 42 Taken together, the findings demonstrate 10 kHz SCS treatment is associated with unique objective physiological responses and sustained pain relief.…”
Section: Discussionmentioning
confidence: 76%
“…10,11,29,33,34 Durable and differentiated outcomes seen with 10 kHz SCS treatment may be attributed to its unique mechanism of action. [35][36][37][38][39][40][41][42] Using in vivo and ex vivo electrophysiological approaches, Lee et al reported that unlike low-intensity (sub-sensory threshold) 1 kHz and 5 kHz SCS, 10 kHz SCS selectively activated inhibitory interneurons in the spinal dorsal horn (DH) and proposed that low-intensity 10 kHz SCS provided paresthesia-free pain relief possibly by activating the inhibitory interneurons without activating dorsal column fibers. 35 Researchers from Chang Gung Memorial Hospital, Taiwan used spared nerve injury…”
mentioning
confidence: 99%
“…In contrast to conventional and burst SCS, evidence from a multicenter RCT has shown that high-frequency SCS delivered at 10 kHz (10 kHz SCS) produces deep and durable paresthesia-free pain relief for chronic neuropathic pain [44,[62][63][64]88,[91][92][93][94][95][96][97]. The specific benefits and unique physiological responses associated with 10 kHz SCS may be attributed to its unique mechanism of action [98][99][100][101][102][103][104][105], although the precise mechanism of action is not yet understood [106].…”
Section: High Frequency (Or 10 Khz) Scsmentioning
confidence: 99%
“…In addition, the authors reported a positive correlation between disability scores and the high-frequency stimulation-induced alpha/theta peak power ratio in patients' frontal and somatosensory brain regions. Investigators who examined human subjects using voxel-based morphometry reported that in subjects with pain due to failed back surgery syndrome who were treated with 10 kHz SCS, pain relief was correlated with bilateral decreases in hippocampal volume, demonstrating an effect of this therapy on structural brain architecture over time [105].…”
Section: High Frequency (Or 10 Khz) Scsmentioning
confidence: 99%
“…Additionally, high-frequency 10 kHz SCS appears to lead to changes in volume of specific brain regions [96]. De Groote et al analyzed hippocampal volumes in 11 individuals with failed back surgery syndrome who underwent HF-SCS implantation.…”
Section: Functional Mri (Mri) In Chronic Pain Patientsmentioning
confidence: 99%