A Regiospecific Synthesis of 1-Heterocyclic Substituted 1,2,4-Triazoles via Addition Reaction of 1,2,4-Triazole With Functionalized Carbodiimide

The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products

“…Some examples of nucleophiles (Nu) include alcohols, amines, thiols, and heterocycles. 4,[54][55][56] While more uncommon, the aza-Wittig/heterocumulenemediated annulation can also be used to produce 5,5-disubstituted imidazol-4-ones. Yang and co-workers reported an interesting cascade of reactions to produce 3,5-dihydro-6Himidazo[1,2-b]-1,2,4-triazol-6-ones (Scheme 17).…”

Efficient Synthesis of 6-(1H-1,2,4-Triazol-1-yl)-thieno[2,3-d]pyrimidin-4(3H)-ones via an Iminophosphorane

“…[10][11][12][13][14] Herein we report an efficient synthesis of 6-(1H-1,2,4-triazol-1-yl)-thieno [2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane 3.…”