2017
DOI: 10.1101/241265
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A Regression-based Framework for Scalable Pathway-guided Search in Genome-wide Association Studies

Abstract: Traditional unbiased genome-wide association studies (GWAS) have successfully identified thousands of loci associated with various complex diseases but there is evidence to suggest that many variants were missed at stringent genome-wide thresholds. Fortunately, there is a rapidly increasing amount of prior knowledge in publicly available genomic datasets and biological databases that can be harnessed to enhance the power of discovering SNPs/Genes from existing or new GWAS datasets. For most diseases, many of t… Show more

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