A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

Abstract

Background
 Coronary artery disease as a consequence of atherosclerosis is the most common cause of morbidity and mortality in type 2 Diabetes Mellitus (DM) patients. Homocysteine (HCY), as one of the risk factors, and uric acid (UA) as the most common antioxidant in serum have their roles in the processes of inflammation and atherogenesis, which underlie the pathogenesis of acute myocardial infarction (AMI). The effect of HCY in cardiovascular disease is thought to manifest primarily through oxidative damage, impling potential correlation between the HCY level and antioxidant status. Since the data related to diagnostic significance of both HCY and UA in diabetic patients with AMI are conflicting, and so far not reported in Bosnian patients, the aim of this research was to examine the association of HCY and UA levels with glomerular filtration rate (eGFR) and explore the pathophysiological significance of these data in Bosnian diabetic patients with AMI.
 Methods
 This prospective research included 52 DM type 2 patients diagnosed with AMI. Blood samples were taken on admission, and used for biochemical analysis. Results of the biochemical analyses were statistically analyzed.
 Results
 Elevated HCY and UA levels were observed in diabetic patients. Females have higher HCY compared to males. Positive correlation was revealed between HCY and UA and was confirmed with different HCY levels in subgroups with different UA level. Negative correlation was observed between UA and HbA1c, as well as between both HCY and UA with eGFR.
 Conclusions
 These results contribute to clarification of the biochemical mechanisms characteristic in AMI patients with DM. According to these results, we believe that joint measurement of HCY and UA could enable a better assessment of the prognosis for this group of patients. This kind of assessment, as well as regression analysis can identify high-risk patients at an earlier stage, when appropriate interventions can influence a better outcome in such patients.

Associations of Homocysteine with B Vitamins and Zinc in Serum Levels of Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

“…The association between uric acid and serum homocysteine can be explained by hydrolysis of S-adenosyl homocysteine leading to the formation of homocysteine and adenosine, because adenosine is degraded to form uric acid as its end-product (32). In the previous studies, the positive correlation between homocysteine and serum uric acid were observed (33)(34)(35), our results are consistent with these studies. However, there are also previous papers which reported that no correlations were found between serum homocysteine and serum uric acid in patients with gout or with uric acid-lowering treatment (36,37).…”

Serum Homocysteine Level Is Positively Correlated With Serum Uric Acid Level in U.S. Adolescents: A Cross Sectional Study

“…However, the above studies have presented inconsistent conclusions with regard to the association between Hcy and SUA. Boras et al ( 20 ) explored the relationship between Hcy levels and SUA in 52 patients with type 2 diabetes mellitus complicated with acute myocardial infarction, and the results showed that Hcy was positively correlated with SUA. Kiseljaković et al ( 19 ) conducted a cross-sectional study of 99 patients with ASCVD and 40 healthy participants.…”

Distribution characteristics and influencing factors of homocyteine in an apparently healthy examined population

“…Studies have pointed out that for every 5 µmol/L increase in blood Hcy, the risk of ischemic heart disease increases by 32%, and every 3 µmol/L decrease in Hcy, the risk of disease is reduced by 16% [ 19 ]. A large number of studies have shown that hyperhomocystaenemia is closely related to the occurrence, development and prognosis of a variety of cardiovascular and cerebrovascular diseases, hypertension, diabetes, and kidney diseases [ 20 – 22 ].…”