A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

Erhart‐Hledik, Jennifer C.; Favre, Julien; Asay, Jessica L.; Smith, R. Lane; Giori, Nicholas J.; Mündermann, Annegret; Andriacchi, Thomas P.

doi:10.1016/j.joca.2012.07.018

Cited by 82 publications

(153 citation statements)

References 42 publications

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“…In accordance with our findings, Berry et al reported that in a group of subjects with knee OA followed for 2 years, changes in levels of COMP correlated with medial cartilage volume loss in subjects with lower-than-average COMP levels 29 . In a recent study by ErhartHledik et al, changes in serum COMP observed after a 30-min walk were correlated with cartilage thickness in the medial femur and tibia over a 5-year period indicating that the mechanical stimulus could better delineate cartilage undergoing increased degradation 37 .…”

Section: Discussionmentioning

confidence: 97%

Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

King

Henneicke

Seibel

et al. 2015

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 97%

Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

King

Henneicke

Seibel

et al. 2015

Osteoarthritis and Cartilage

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“…Therefore, monitoring biomarkers is important for early prevention and treatment of OA before significant articular cartilage damage or imaging changes occur (Halász et al, 2007;Koskinen et al, 2011). Research has revealed that a variety of matrix metalloproteinases and cytokines are involved in articular cartilage destruction, which arises from a complex network of factors rather than from a single cause (Li et al, 2011;Erhart et al, 2012). MMP-3 is a protease that can degrade the cartilage matrix.…”

Section: Discussionmentioning

confidence: 99%

Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model

Xq¹,

Wang²,

Ld³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed for 2, 4, and 6 weeks, respectively; and groups L1, L2, and L3, in which breaking was discontinued for 2, 4, and 6 weeks, respectively, following a 4-week recovery period. There are 7 rabbits in each group. The degree of cartilage damage in each group was scored (OA score). An enzyme-linked immunosorbent assay was used to detect COMP and MMP-3 levels in serum and joint fluid. The OA scores were 3.89 ± 2.31, 7.21 ± 2.31, and 10.88 ± 2.08 points in groups M1, M2, and M3, respectively (P < 0.05). COMP and MMP-3 levels were significantly 14208 X.Q. Chu et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 14207-14215 (2015) higher in groups M1, M2, and M3 than in C. The OA score improved significantly following the 4-week recovery period (P < 0.05). COMP and MMP-3 levels began to decrease as the time following discontinuation of breaking increased, but were higher than in the control (P < 0.05). MMP-3 and COMP levels were correlated with OA score (r > 0.7, P < 0.05). COMP and MMP-3 levels were correlated between joint fluid and serum (r = 0.899, r = 0.874, P < 0.05, respectively). Long-term joint breaking can cause articular cartilage damage. Doing some activites after the process can promote self-repair of articular cartilage. COMP and MMP-3 levels were associated with articular cartilage destruction and repair.

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“…A recent study 19 used COMP as a surrogate biological component with a 30 minute walk as the mechanical component and cartilage change over 5 years as the structural component and thus reduced the conceptual systems model (Figure 1) to a practical framework with measurable components. The model was then used in a stimulus-response framework where the mechanical component (30 minute walk) was used to stimulate a biological response (change in COMP concentration from resting) with the structural component (cartilage thickness change over 5 years) investigated as the outcome.…”

Section: New Approaches To the Early Detection Of Oamentioning

confidence: 99%

A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease

et al. 2014

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Early detection of osteoarthritis (OA) remains a critical yet unsolved multifaceted problem. To address the multifaceted nature of OA a systems model was developed to consolidate a number of observations on the biological, mechanical and structural components of OA and identify features common to the primary risk factors for OA (aging, obesity and joint trauma) that are present prior to the development of clinical OA. This analysis supports a unified view of the pathogenesis of OA such that the risk for developing OA emerges when one of the components of the disease (e.g. mechanical) becomes abnormal, and it is the interaction with the other components (e.g. biological and/or structural) that influences the ultimate convergence to cartilage breakdown and progression to clinical OA. The model, applied in a stimulus-response format, demonstrated that a mechanical stimulus at baseline can enhance the sensitivity of a biomarker to predict cartilage thinning in a five year follow-up in patients with knee OA. The systems approach provides new insight into the pathogenesis of the disease and offers the basis for developing multidisciplinary studies to address early detection and treatment at a stage in the disease where disease modification has the greatest potential for a successful outcome.

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A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

Cited by 82 publications

References 42 publications

Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

Association of adipokines and joint biomarkers with cartilage-modifying effects of weight loss in obese subjects

Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model

A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease

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