A relative comparison of antibacterial strength between platelet lysate and platelet factor 4 in vitro

Abstract

Background Recently the role of platelets in the tissue regeneration, wound healing, and prevention and control of infections have been reported. The treatment of bacterial infections has become a global challenge due to the spread of multidrug-resistant bacteria; therefore, the development of new treatment options for the mentioned infections is essential. We assessed the antibacterial effect of human platelet lysate (PL) and platelet factor 4 (PF4) on bacteria commonly found in nosocomial infections. Methods In this study, the antibacterial activity of PL and PF4 was tested on Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Enterococcus faecalis, Acinetobacter baumannii by well diffusion and serial micro-dilution methods. Results In vitro results showed that PF4 inhibited the growth of S. aureus, E. faecalis A. baumannii, as a new antibacterial agent. While PL had no discernible impact on the growth parameters of any bacterium tested. Conclusion PF4 that is a biocompatible and safe product could be potentially useful in nosocomial infections. The use of PF4 is an attractive strategy for treating A. baumannii and S. aureus, E. faecalis nosocomial infections because it inhibits bacterial growth.