A relay model of human sleep stages

Putilov, Arcady A.; Kovalzon, Vladimir M.; Dorokhov, Vladimir B.

doi:10.1140/epjs/s11734-023-01059-1

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The model also predicts such a well-known fact as a gradual increase in the interval of REM sleep from one NREM-REM sleep cycle to another throughout an all-night sleep episode. Given that stages N2 and N3 of NREM sleep are characterized by pos-itive PC1 scores while PC1 score is negative for other stages [17], the increase in the interval of negative PC1 scores in a sequence of sleep cycles reflects a gradual increase in duration of REM sleep during the end of cycle (Figure 2B) that was predicted in the in silico study (Figure 1B,C).…”

Section: Results Of Simulation Studymentioning

confidence: 66%

“…Table S1 in Supplementary Material contains the preliminary results of simulations of two different spectral EEG indexes of sleep regulation, the traditional index, SWA measured as ln-transformed spectral power densities averaged in the range 1-4 Hz, and PC1 score. When SWA can reflect the contribution of both drives for sleep and wake [27], PC1 score was proposed to be a separate indicator of the drive for sleep, while the opposing drive, for wake, can be represented for the second principal component [17,27].…”

Section: Estimation Of Spectral Eeg Indicators Of Processes S and Smentioning

confidence: 99%

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Can the Brain’s Thermostatic Mechanism Generate Sleep-Wake and NREM-REM Sleep Cycles? A Nested Doll Model of Sleep-Regulating Processes

Putilov

2024

Clocks & Sleep

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Evidence is gradually accumulating in support of the hypothesis that a process of thermostatic brain cooling and warming underlies sleep cycles, i.e., the alternations between non-rapid-eye-movement and rapid-eye-movement sleep throughout the sleep phase of the sleep-wake cycle. A mathematical thermostat model predicts an exponential shape of fluctuations in temperature above and below the desired temperature setpoint. If the thermostatic process underlies sleep cycles, can this model explain the mechanisms governing the sleep cyclicities in humans? The proposed nested doll model incorporates Process s generating sleep cycles into Process S generating sleep-wake cycles of the two-process model of sleep-wake regulation. Process s produces ultradian fluctuations around the setpoint, while Process S turns this setpoint up and down in accord with the durations of the preceding wake phase and the following sleep phase of the sleep-wake cycle, respectively. Predictions of the model were obtained in an in silico study and confirmed by simulations of oscillations of spectral electroencephalographic indexes of sleep regulation obtained from night sleep and multiple napping attempts. Only simple—inverse exponential and exponential—functions from the thermostatic model were used for predictions and simulations of rather complex and varying shapes of sleep cycles during an all-night sleep episode. To further test the proposed model, experiments on mammal species with monophasic sleep are required. If supported, this model can provide a valuable framework for understanding the involvement of sleep-wake regulatory processes in the mechanism of thermostatic brain cooling/warming.

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Section: Results Of Simulation Studymentioning

confidence: 66%