A remotely controlled production system for routine preparation of [methyl-11C]thymidine

Goethals, Patrick; Sambre, J.; Coene, M.‐C.; Casteleyn, K.; Poupeye, E.

doi:10.1016/0883-2889(92)90165-b

Cited by 15 publications

(5 citation statements)

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“…A m : 3 GBq/μmol for [ 11 C]CH 2 O at EOB) . To increase yields and A m and allow for automation, alternative preparations utilizing [ 11 C]CH 3 I were developed and used in clinical tracer productions. ,− To increase yields and A m and allow for automation, alternative preparations utilizing [ 11 C]CH 3 I were developed and used in clinical tracer productions. ,,, In this approach, 5-bromo-2′-deoxyuridine derivatives bearing trimethylsilyl ,, or tetrahydropyranyl ,, hydroxyl protecting groups are lithiated, then 11 C-methylated to produce [ methyl - 11 C]thymidine after protecting group removal (Figure B). Time: 30–35 min.…”

Section: Nucleotides Nucleosides and Nucleobasesmentioning

confidence: 98%

“…702,730−733 To increase yields and A m and allow for automation, alternative preparations utilizing [ 11 C]CH 3 I were developed and used in clinical tracer productions. 731,732,734,735 In this approach, 5-bromo-2′-deoxyuridine derivatives bearing trimethylsilyl 730,733,736 or tetrahydropyranyl 730,733,736 hydroxyl protecting groups are lithiated, then 11 C-methylated to produce [methyl- 11 C]thymidine after protecting group removal (Figure 152B). Time: 30−35 min.…”

Section: Nucleotides Nucleosides and Nucleobasesmentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

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Section: Nucleotides Nucleosides and Nucleobasesmentioning

confidence: 98%

Section: Nucleotides Nucleosides and Nucleobasesmentioning

confidence: 99%

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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“…For a routine thymidine scan we normally administer about 0.1 pmol. Thymidine can be labelled with "C either in the methyl position (8) or in the ring-2 position (20). The labelling in the ring-2 seems preferable since the labelled carbon is presumed to be exhaled as "C02 during metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Chemically and radiochemically pure [methyl-"Clthymidine was produced starting from "CO, as has been described previously (8). The specific activity at time of injection was 7.4 to 9.3 GBq pmol-' and the tracer was dissolved in 8ml of isotonic phosphate buffer.…”

Section: Methodsmentioning

confidence: 99%

Kinetics of [methyl-¹¹C]Thymidine in Patients with Squamous Cell Carcinoma of the Head and Neck

et al. 1996

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“…(4,5) In a conical 5 ml reaction vial, 2.5 mg (7.5 mmol) of ciprofloxacin was dissolved in 200 ml DMF. Four millilitres of TBA (6.0 mmol) was added as base.…”

Section: Preparation Of Nmentioning

confidence: 99%

Preparation of N′₄‐[¹¹C]methyl‐ciprofloxacin for positron emission tomography studies

Goethals

Volkaert²

2002

Labelled Comp Radiopharmac

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SummaryThe synthesis of N 4 0 -[ 11 C]methyl-ciprofloxacin for pharmacological studies using positron emission tomography is described. The starting material was treated with [ 11 C]methyl iodide at 1208C in DMF for 5 min. After HPLC separation on a C 18 -column with water/ethanol as mobile phase, the [ 11 C]methyl labelled compound was produced with a radiochemical yield of at least 25% (end of synthesis from [ 11 C]CO 2 ). Activities from 1.48 to 2.22 GBq (40 to 60 mCi) were obtained 1 h after the irradiation, ready for intravenous injection. The carrier ranged between 0.05 and 0.08 mmol (0.010-0.016 mmol/ml).

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A remotely controlled production system for routine preparation of [methyl-11C]thymidine

Cited by 15 publications

References 5 publications

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Kinetics of [methyl-¹¹C]Thymidine in Patients with Squamous Cell Carcinoma of the Head and Neck

Preparation of N′₄‐[¹¹C]methyl‐ciprofloxacin for positron emission tomography studies

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A remotely controlled production system for routine preparation of [methyl-11C]thymidine

Cited by 15 publications

References 5 publications

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Kinetics of [methyl-11C]Thymidine in Patients with Squamous Cell Carcinoma of the Head and Neck

Preparation of N′4‐[11C]methyl‐ciprofloxacin for positron emission tomography studies

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Kinetics of [methyl-¹¹C]Thymidine in Patients with Squamous Cell Carcinoma of the Head and Neck

Preparation of N′₄‐[¹¹C]methyl‐ciprofloxacin for positron emission tomography studies