A Renal Action of Glucagon

Staub, Alfred; Springs, Vivien; Stoll, Fabian; Elrick, Harold

doi:10.3181/00379727-94-22854

Cited by 50 publications

(19 citation statements)

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“…The decreases in plasma sodium and potassium concentrations during glucagon infusion are consistent with earlier observations on cats (Wolfson and Ellis 1956) and may be partly due to increased renal excretion of sodium and potassium seen after glucagon administration (Staub et al 1957). …”

Section: (D) Plasma Urea Sodium and Potassium Ooncentrationssupporting

confidence: 80%

The Effects of Glucagon on Plasma Concentrations of Insulin. Growth Hormone, Glucose and Free Fatty Acids in Sheep: Comparison with the Effects of Catecholamines

Bassett¹

1971

Aust. Jnl. Of Bio. Sci.

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Glucagon, adrenaline, and isoprenaline were administered to adult sheep by intravenous infusion at a rate of 5 p.g/min for 2 hr.Plasma glucose concentration increased more rapidly during glucagon infusion than during infusion of either adrenaline or isoprenaline.Plasma insulin concentration increased rapidly during glucagon infusion, but the increase was less than that observed during infusion of isoprenaline. There was almost no increase in plasma insulin during infusion of adrenaline despite marked hyperglycaemia.Plasma growth hormone concentration increased during glucagon infusion, but high levels were not maintained. Both adrenaline and isoprenaline decreased growth hormone concentration.Plasma free fatty acid concentrations decreased during glucagon infusion. Plasma sodium and potassium concentrations also decreased but the plasma concentration of urea nitrogen was not altered during glucagon infusion.Intravenous infusion of glucagon at rates of 0·5 and O· 1 p.g/min for 2 hr also significantly increased plasma glucose, insulin, and growth hormone concentration and decreased plasma free fatty acid concentration. Infusion of glucagon at lower rates (0·05 and 0·01 p.g/min) had no significant effects.

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Section: (D) Plasma Urea Sodium and Potassium Ooncentrationssupporting

confidence: 80%

The Effects of Glucagon on Plasma Concentrations of Insulin. Growth Hormone, Glucose and Free Fatty Acids in Sheep: Comparison with the Effects of Catecholamines

Bassett¹

1971

Aust. Jnl. Of Bio. Sci.

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“…However, Benjamin, and Singer (40) recently have reported that both insulin and aldosterone increase sodium transport in the toad urinary bladder; this effect occurs in association with the induction of a low molecular weight protein. These observations lend support Recently, glucagon administered in pharmacologic doses has been shown to be natriuretic (23,26). Because increases in plasma insulin concentration are known to be accompanied by reciprocal changes in circulating levels of glucagon (41), the possibility exists that lowering of endogenous glucagon concentration during our insulin infusion studies may have contributed to the antinatriuresis which was observed.…”

Section: Discussionsupporting

confidence: 50%

“…Plasma glucagon concentration increases during fasting and decreases during refeeding (21,22). Since glucagon is known to have natriuretic properties (23)(24)(25)(26), sodium retention during refeeding could be related, at least in part, to a reduction in plasma glucagon concentration. However, carbohydrate-stimulated insulin secretion is also temporally related to sodium retention, and one may reasonably raise the question whether insulin plays a role in this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

DeFronzo¹,

Cooke²,

Andres³

et al. 1975

J. Clin. Invest.

1,035

418

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A B S T R A C T The effects of insulin on the renal handling of sodium, potassium, calcium, and phosphate were studied in man while maintaining the blood glucose concentration at the fasting level by negative feedback servocontrol of a variable glucose infusion. In studies on six water-loaded normal subjects in a steady state of water diuresis, insulin was administered i.v. to raise the plasma insulin concentration to between 98 and 193 PU/ml and infused at a constant rate of 2 mU/kg body weight per min over a total period of 120 min. The blood glucose concentration was not significantly altered, and there was no change in the filtered load of glucose; glomerular filtration rate (CIN) and renal plasma flow (CPAH) were unchanged. Urinary sodium excretion (UNaV) decreased from 401±46 (SEM) to 213+18 iteq/min during insulin administration, the change becoming significant (P < 0.02) within the 30-60-min collection period. Free water clearance (CH2o) increased from 10.6±0.6 to 13±0.5 ml/min (P <0.025); osmolar clearance decreased and urine flow was unchanged. There was no change in plasma aldosterone concentration, which was low throughout the studies, and a slight reduction was observed in plasma glucagon concentration. Urinary potassium (UKV) and phosphate (Ui.V) excretion were also both decreased during insulin administration; UKV decreased from 66±9 to 21±1 Meq/min (P < 0.005), and UrV decreased from 504±93 to 230 ±43 Ag/min (P <0.01). The change in UKV was associated with a significant reduction in plasma potassium concentration. There was also a statistically significant but small reduction in plasma phosphate concentration which was not considered sufficient alone to account for the large reduction in UPV. Urinary calcium excretion (UCaV) increased from 126±24 to 200±17 ug/min (P < 0.01).These studies demonstrate a reduction in UNaV associated with insulin administration that occurs in the absence of changes in the filtered load of glucose, glomerular filtration rate, renal blood flow, and plasma aldosterone concentration. The effect of insulin on CH2o suggests that insulin's effect on sodium excretion is due to enhancement of sodium reabsorption in the diluting segment of the distal nephron.

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“…Several previous studies have shown that glucagon exerts natriuretic and phosphaturic effects (5,(47)(48)(49)(50)(51) by reducing the reabsorption of sodium, phosphate, and water in the whole proximal tubule, with a predominant influence in the pars recta (52). However, no glucagon receptors (53) and no glucagon-sensitive adenylate cyclase activity (54) have been found in this nephron segment.…”

Section: Groups Plasma Urea (Mm)mentioning

confidence: 72%

Cyclic AMP is a hepatorenal link influencing natriuresis and contributing to glucagon-induced hyperfiltration in rats.

Ahloulay¹,

Déchaux²,

Hassler³

et al. 1996

J. Clin. Invest.

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The effects of glucagon (G) on proximal tubule reabsorption (PTR) and GFR seem to depend on a prior action of this hormone on the liver resulting in the liberation of a mediator and/or of a compound derived from amino acid metabolism. This study investigates in anesthetized rats the possible contribution of cAMP and urea, alone and in combination with a low dose of G, on phosphate excretion (known to depend mostly on PTR) and GFR. After a 60-min control period, cAMP (5 nmol/min ϫ 100 grams of body weight [BW]) or urea (2.5 mol/min ϫ 100 grams BW) was infused intravenously for 200 min with or without G (1.2 ng/min ϫ 100 grams BW, a physiological dose which, alone, does not influence PTR or GFR). cAMP increased markedly the excretion of phosphate and sodium ( ϩ 303 and ϩ 221%, respectively, P Ͻ 0.01 for each) but did not alter GFR. Coinfusion of cAMP and G induced the same tubular effects but also induced a 20% rise in GFR ( P Ͻ 0.05). Infusion of urea, with or without G, did not induce significant effects on PTR or GFR. After G infusion at increasing doses, the increase in fractional excretion of phosphate was correlated with a simultaneous rise in plasma cAMP concentration and reached a maximum for doubling of plasma cAMP. These results suggest that cAMP, normally released by the liver into the blood under the action of G, ( a ) is probably an essential hepatorenal link regulating the intensity of PTR, and ( b ) contributes, in conjunction with specific effects of G on the nephron, to the regulation of GFR. ( J. Clin. Invest. 1996. 98: 2251-2258.)

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A Renal Action of Glucagon

Cited by 50 publications

References 0 publications

The Effects of Glucagon on Plasma Concentrations of Insulin. Growth Hormone, Glucose and Free Fatty Acids in Sheep: Comparison with the Effects of Catecholamines

The Effects of Glucagon on Plasma Concentrations of Insulin. Growth Hormone, Glucose and Free Fatty Acids in Sheep: Comparison with the Effects of Catecholamines

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

Cyclic AMP is a hepatorenal link influencing natriuresis and contributing to glucagon-induced hyperfiltration in rats.

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