A report of chronic intestinal pseudo-obstruction related to systemic lupus erythematosus

Abstract

<jats:title>Abstract</jats:title><jats:p>Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Reports about reduplicated CIPO as a complication of SLE is infrequent. A 49-year-old female suffering from clinical symptoms of ileus has been hospitalized 3 times over 1 year. Her examination results showed no observation of mechanical obstruction. In August 2017, she came to the nephrology department due to edema in both lower limbs along with symptoms of ileus. After thorough examination, she was diagnosed with secondary CIPO related to SLE. Results of renal biopsy confirmed to be lupus nephritis (Class III-(A) + V). The symptoms of ileus are gradually improved after treatment of full-dose intravenous corticosteroid for 5 days.</jats:p>

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

“…However, no detailed information about the DDIs between tacrolimus and nirmatrelvir/ritonavir in these patients were reported. SLE was reported to be associated with intestinal pseudo-obstruction, especially when the disease was active ( Zhang et al, 2016 ; Wang et al, 2018 ). However, the SLE disease activity index of our case scored 2, while the SLE disease activity score was 1.12, both indicating remission of the disease.…”

Systemic Sclerosis Sine Scleroderma as a Rare Etiology of Chronic Intestinal Pseudo-Obstruction

“…3 While the majority of CIPO patients are idiopathic, many secondary etiologies cause CIPO, including the following: infectious (Chagas), neurologic (stroke, Parkinson's disease, Hirschsprung's disease), paraneoplastic (carcinoid tumors, central nervous system [CNS] neoplasms, leiomyosarcomas), endocrine (diabetes, hypothyroidism, and hypoparathyroidism), genetic (Duchenne muscular dystrophy, mitochondrial, neurogastrointestinal, encephalomyopathy, and other neuronal or SMC mutations), autoimmune diseases (systemic sclerosis, SLE, and dermatomyositis), or iatrogenic causes (radiation, antidepressants, antiparkinsonian agents, and antineoplastics). 1,3,4 Diagnosis of CIPO is challenging as it inconsistently affects parts of the gastrointestinal tract. 3 Small bowel involvement causes weight loss and vomiting; large bowel involvement causes abdominal pain, distension, and constipation; and esophageal involvement causes dysphagia and gastroesophageal reflux.…”