A report of the frequency of colorectal carcinoma and involved lymph nodes in South-West Iran

Shahbazian, Heshmatolah; Nasuri, Yaser; Hosseini, Seyed Mohammad; Arvandi, Shole; Razzaghi, Samira

doi:10.4103/0971-5851.177014

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Therefore, it is well-known to check the association with clinical parameters, and it is necessary to perform disease management based on this. In addition, due to the development of many studies and techniques, the pathogenesis and diagnosis methods of CRC are developing, and the rate of CRC treatment by early diagnosis is increasing (25,26,48,49). However, despite advances in technology, people in blind spots, those with the burden of medical expenses and the difficulties of living conditions do not receive these benefits (50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants of HOTAIR Associated With Colorectal Cancer Susceptibility and Mortality

et al. 2020

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In colorectal carcinogenesis, the unique molecular and genetic changes that occur within cells result in specific CRC phenotypes. The involvement of the long non-coding RNA, HOTAIR, in cancer development, progression, and metastasis is well-established. Various studies have reported on the contribution of HOTAIR to cancer pathogenesis. Therefore, we selected four HOTAIR polymorphisms (rs7958904G>C, rs1899663G>T, rs4759314A>G, and rs920778T>C) to evaluate the association of each variant with CRC prevalence and prognosis. We conducted a case-control study of 850 individuals to identify the genotype frequencies of each polymorphism. The study population included 450 CRC patients and 400 control individuals that were randomly selected following a health screening. Notably, rs7958904 and rs1899663, their hetero genotype, and the dominant model were significantly different when compared to the healthy control group (rs7958904; AOR = 1.392, 95% CI = 1.052-1.843, P = 0.021). To evaluate the effect of HOTAIR polymorphisms on the survival rate, we analyzed patient mortality and relapse occurrence within 3 and 5 years with Cox-regression analysis. The rs7958904 CC polymorphism mortality rate was significantly higher than the GG polymorphism mortality rate (adjusted HR = 2.995, 95% CI = 1.189-7.542, P = 0.021). In addition, the rs920778 CC genotype was significantly different than the TT genotype (adjusted HR = 3.639, 95% CI = 1.435-9.230, P = 0.007). In addition, this study confirmed that genetic variants of HOTAIR alter the mRNA expression level (P < 0.01). We suggest that HOTAIR rs7958904G>C which is associated with CRC prevalence and mortality is a potential biomarker for CRC. The association between HOTAIR gene polymorphisms and CRC prevalence were reported for the first time.

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Section: Discussionmentioning

confidence: 99%

Genetic Variants of HOTAIR Associated With Colorectal Cancer Susceptibility and Mortality

et al. 2020

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“…Colon cancer, as the third most common type of malignant tumor in the world, seriously affects human health (12). Despite the efforts made in cancer diagnosis, many cancer patients are still diagnosed at advanced stages.…”

Section: Discussionmentioning

confidence: 99%

Effect of lncRNA�THOR on proliferation and igration of colon cancer cells

Yang

Wang

2019

Oncol Lett

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The effect of long non-coding RNA (lncRNA) THOR on proliferation and migration of colon cancer cells was investigated. Lentiviral vector expressing lncRNA THOR shRNA was used to establish colon cancer SW620 lncRNA THOR knockdown cell line (experimental group), and at the same time, a control vector cell line (control group) was established by empty vector virus. Proliferation ability of the two groups was analyzed by CCK8 and EdU methods. Migration ability of the cells was analyzed by Transwell method. Xenograft tumor method was used to analyze the in vivo proliferation ability of the two groups of cells. mRNA levels of lncRNA THOR target genes were analyzed by reverse transcription-quantitative PCR (RT-qPCR). Compared with control cells, the cell proliferation ability of the experimental group was significantly decreased (P<0.05). Compared with the control group, the cell migration ability of the experimental group was significantly decreased (P<0.05). The tumor growth rate of the experimental group in the mice was significantly lower than that of the control group (P<0.05). Compared with the control group, mRNA levels of lncRNA THOR target genes IGF2BP1, SOX9 and c-myc in the experimental group were significantly downregulated (P<0.05). The results indicated that lncRNA THOR knockdown can significantly downregulate the expression of genes involved in tumor proliferation and migration, promote tumor cell proliferation and migration, indicating that lncRNA THOR plays an important role in colon cancer.

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“…Gene–gene interactions among the four lncRNA loci were analyzed using the multifactor dimensionality reduction (MDR) method in MDR software version 2.0 ( ) (accessed on 6 October 2022). (released in 2008) [ 28 ]. Using the MDR method, we evaluated the frequencies of all combinations of the four polymorphisms, followed by Fisher’s exact test to adjust for multiple comparisons.…”

Section: Methodsmentioning

confidence: 99%

Association of Polymorphisms in the Long Non-Coding RNA HOTAIR with Recurrent Pregnancy Loss in a Korean Population

Park

Kim

Lee

et al. 2022

Genes

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Recurrent pregnancy loss (RPL) affects 1% to 5% of women, with devastating effects on both reproductive health and psychological well-being. Homeobox (HOX) transcript antisense RNA (HOTAIR) is a long non-coding RNA (lncRNA) produced by HOXC; it plays a major role in invasion and development of ovarian and other cancers. The aim of the present study was to analyze effects of HOTAIR polymorphisms (rs4759314 A>G, rs920778 T>C, rs1899663 G>T, and rs7958904 G>C) on RPL in Korean women. A total of 403 women with RPL and 383 healthy women were selected for this study. Genotyping analysis was performed with the polymerase chain reaction, restriction fragment length polymorphism, and the TaqMan genotyping assay. Clinical characteristics were compared using Student’s unpaired t-test and the chi-square test for categorical variables. Logistic regression was performed to evaluate associations between single nucleotide polymorphisms and RPL incidence. In all assays, p < 0.05 was considered significant. HOTAIR polymorphisms rs4759314A>G and rs920778T>C were highly associated with increased risk of RPL, specifically the haplotypes rs4759314A>G/rs1899663G>T (G-T) and rs4759314A>G/rs920778 T>C (G-C). These associations were maintained in haplotypes that contained three polymorphisms (rs4759314 A>G, rs920778 T>C, and rs1899663 G>T) A-C-G, G-T-G, and G-T-T, further indicating that the HOTAIR rs4759314 and rs920778 polymorphisms play significant roles in idiopathic RPL in Korean women.

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A report of the frequency of colorectal carcinoma and involved lymph nodes in South-West Iran

Cited by 6 publications

References 13 publications

Genetic Variants of HOTAIR Associated With Colorectal Cancer Susceptibility and Mortality

Genetic Variants of HOTAIR Associated With Colorectal Cancer Susceptibility and Mortality

Effect of lncRNA�THOR on proliferation and igration of colon cancer cells

Association of Polymorphisms in the Long Non-Coding RNA HOTAIR with Recurrent Pregnancy Loss in a Korean Population

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