A report on two interlaboratory surveys of serum ferritin estimation

Blunden, Robert W.; Farley, John R.; Geary, T.D.; Halliday, June W.; Hawley, Daniel; Rudzki, Zbigniew

doi:10.3109/00313028009086810

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…As shown in S1 Table (supplementary material), some of the studies report calibrating the assays to WHO or other international reference materials, although calibration data is not presented in the articles [ 8 , 10 , 18 , 36 , 38 , 45 , 54 , 62 , 78 , 79 , 85 , 95 , 112 , 115 , 116 , 126 , 131 , 136 , 137 , 139 , 140 , 142 , 148 , 155 , 156 , 158 , 162 , 164 , 168 , 171 , 187 , 190 ]. There were no studies reporting the use of these materials on a laboratory routine basis.…”

Section: Resultsmentioning

confidence: 99%

Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis

et al. 2018

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BackgroundDifferent laboratory methods are used to quantify ferritin concentrations as a marker of iron status. A systematic review was undertaken to assess the accuracy and comparability of the most used methods for ferritin detection.Methods and findingsNational and regional databases were searched for prospective, retrospective, sectional, longitudinal and case-control studies containing the characteristics and performance of at least one method for serum/plasma ferritin determinations in humans published to date. The analysis included the comparison between at least 2 methods detailing: sensitivity, precision, accuracy, predictive values, inter-methods adjustment, and use of international reference materials. Pooled method performance was analyzed for each method and across methods.OutcomesSearch strategy identified 11893 records. After de-duplication and screening 252 studies were assessed, including 187 studies in the qualitative analysis and 148 in the meta-analysis. The most used methods included radiometric, nonradiometric and agglutination assays. The overall within-run imprecision for the most reported ferritin methods was 6.2±3.4% (CI 5.69–6.70%; n = 171), between-run imprecision 8.9±8.7% (CI 7.44–10.35%; n = 136), and recovery rate 95.6% (CI 91.5–99.7%; n = 94). The pooled regression coefficient was 0.985 among all methods analyzed, and 0.984 when comparing nonradiometric and radiometric methods, without statistical differences in ferritin concentration ranging from 2.3 to 1454 μμg/L.ConclusionThe laboratory methods most used to determine ferritin concentrations have comparable accuracy and performance. Registered in PROSPERO CRD42016036222.

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Section: Resultsmentioning

confidence: 99%

Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis

et al. 2018

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Developmental changes in serum ferritin and erythrocyte protoporphyrin in normal (nonanemic) children

Deinard¹,

Schwartz²,

Yip³

1983

The American Journal of Clinical Nutrition

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We studied 4039 children who were 6 months to 12 yr of age to characterize developmental variations of serum ferritin and erythrocyte protoporphyrin. Age-related descriptive statistics were derived. The -2 SD value for serum ferritin was found to increase progressively from 12 to 21 micrograms/1 with increasing age, while the +2 SD value for erythrocyte protoporphyrin was found to decrease progressively from 65 to 42 micrograms/dl whole blood with increasing age. While the mean serum ferritin value was found to continue to rise throughout the first 12 yr of life, erythrocyte protoporphyrin values were highest at 1 to 2 yr of age, then fell to essentially constant levels after 4 to 6 yr of age. These relationships, as well as the linear relationship of increasing hematocrit and serum ferritin with increasing age, suggest that the rise of hematocrit with age, as previously observed, is associated with improving storage and availability of iron for heme synthesis.

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A report on two interlaboratory surveys of serum ferritin estimation

Cited by 2 publications

References 6 publications

Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis

Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis

Developmental changes in serum ferritin and erythrocyte protoporphyrin in normal (nonanemic) children

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