A reporter assay for the next generation of biomaterials: Porous‐wall hollow glass microspheres

Cunningham, Aaron J.; Faircloth, Hunter A.; Jones, Max; Johnson, Christopher P.; Coleman, Tiffany; Wicks, G.G.; Postma, Gregory N.; Weinberger, Paul M.

doi:10.1002/lary.24414

Cited by 3 publications

(2 citation statements)

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“…One of the most interesting and unique glass microsphere morphologies is porous wall hollow glass microspheres (PWHGMs). These microspheres were first developed at the Savannah River National Laboratory for nuclear‐related uses, but they have found over a dozen applications in many other areas including energy, environmental remediation, homeland defense, and medicine . On the cover of a special IJAGS edition on “Glass for the 21st Century”, a micrograph of a filled PWHGM was shown and the potential of PWHGMs for medical applications was described briefly in an article by Prof. Larry Hench in that publication entitled “Glass and Glass Technologies to Transform the World” and later in more detail in Larry Hench's textbook Introduction to Bioceramics, 2nd edition .…”

Section: Mini Review Results and Discussionmentioning

confidence: 99%

Tiny Bubbles; Composite Cocktails for Medical Applications

Wicks¹,

Hill

Weinberger

2016

Int J of Appl Glass Sci

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Tiny bubbles or glass microspheres/microcapsules are used in our society today in many ways. The microspheres can be solid or hollow and represent particles that are generally in the range of 0.1–100 μm. Solid and hollow microspheres have significantly different densities, properties, and capabilities and are commercially available. Special morphologies, formulations, and compositions can also be achieved by a variety of techniques in the laboratory. One of the most interesting morphologies of these tiny bubbles, are porous wall hollow glass microspheres, which are glass micro‐balloons in which through‐wall porosity was induced in the thin outer shells and controlled, on a scale of 10–100 nm. This unique porosity can be used to fill the microspheres with a variety of cargos of various contents that can later be released on demand. For medical applications, an interdisciplinary team investigated these tiny bubbles, as part of a new series of composites or medical cocktails. The microspheres are key components in the composites and can be used alone or mixed in various amounts and ratios, with a variety of contents, outer coatings, and/or biocompatible matrices, resulting in a wide range of medical cocktails designed and tailored for various applications.

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Section: Mini Review Results and Discussionmentioning

confidence: 99%

Tiny Bubbles; Composite Cocktails for Medical Applications

Wicks¹,

Hill

Weinberger

2016

Int J of Appl Glass Sci

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“…The reports on the application of QDs for regenerative medicine as another nanomedicine domain are currently limited to a couple of dozens and are mostly related to testing of the innovative tissue engineering systems performance [104,105] or stem cells tracking using QDs as fluorescent labels [106,107] and therefore are not discussed in detail in the current review.…”

Section: Quantum Dots For Diagnostics and Therapymentioning

confidence: 99%

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Volkov

2015

Biochemical and Biophysical Research Communications

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a b s t r a c tThe review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including "classical" semiconductor groups III-V and II-VI nanocrystals, along with more recently emerged carbon, silicon, gold and other types of nanoparticles falling into this class of nanomaterials due to their similar physical characteristics such as small size and associated quantum confinement effects. A diverse range of QDs applications in nanomedicine has been extensively summarised previously in numerous publications. Therefore, this review is not intended to provide an all-embracing survey of the well documented QDs uses, but is rather focused on the most recent emerging developments, concepts and outstanding unresolved problematic and sometimes controversial issues. Over 125 publications are overviewed and discussed here in the context of major nanomedicine domains, i.e. medical imaging, diagnostics, therapeutic applications and combination of them in multifunctional theranostic systems.© 2015 Elsevier Inc. All rights reserved. Quantum dots in nanomedicine: recent trendsWithin a steadily increasing database of diverse nanomaterials reported as suitable for applications in nanomedicine [1e10], quantum dots (QDs) deservedly occupy a special niche as nanoparticles with a unique track record full of high expectations, dramatic pitfalls and often controversial experimental evidence. From the early optimistic aspirations of them as breakthrough tools for multipurpose in vitro and in vivo applications [11e17], they have been subject to a period of partial relinquishment following the sombre realisation that in the original unmodified state QDs did not stand a chance to deserve a unanimous approval as imaging or drug delivery vehicles in humans, due to their intrinsic toxicity and lack of biodegradability perspective. The disappointingly low yield of exploitable outputs following the initial rounds of heavy investments in the field has also contributed to the overall decline in research productivity metrics. The analysis of the recent ten years' trends in publications number in this area related to the QDs medical applications in vivo in general (Fig. 1 A), as well as for imaging and diagnostics purposes (Fig. 1 B, C) according to Thomson Reuters Web of Science™ database clearly reflects such "cooling down" period after 2010 resulting in a significant reduction in the initially steady exponential growth of publication rates. This trend has been partially or completely reversed by 2014 and it is intriguing whether we will see it sustained in 2015 and beyond.Such returning enthusiasm has been reinvigorated by a number of objective tendencies in the related technological developments, including the arrival of innovative nanotechnology-enabled tools for diagnostic and ex vivo imaging applications [18,19], the arrival of new types of QDs of alternative nature offering the opportunities of r...

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