A reporting system for endometrial cytology: Cytomorphologic criteria—Implied risk of malignancy

Abstract

We propose a clinically oriented classification scheme consisting of diagnostic categories with well determined criteria. Each diagnostic category is linked with an implied risk of malignancy; thus, clinicians may decide on patient management and eventually reduce unnecessary interventional diagnostic procedures. Diagn. Cytopathol. 2016;44:888-901. © 2016 Wiley Periodicals, Inc.

Internal quality control in an academic cytopathology laboratory for the introduction of a new reporting system for endometrial cytology

“…The “nondiagnostic/unsatisfactory” category was excluded; moreover, the metrics were extracted when ACE‐U cases ware considered as corresponding to the “benign” or “malignant” category of histologic results. Since the risk of malignancy for ACE‐U cases according to our previous study was 44.44 ± 32.46%, a non negligible percentage, which cannot be left without further clinical investigation, to the authors' opinion ACE‐U cases should be considered as malignant, moreover the 15 answers given from the 5 cytopathologist were relevant to 11 cases, from these, 6 cases were histologically malignant, and 5 benign.…”

“…Nevertheless, most cytologic classification reporting schemes usually rely upon histologic reporting formats, thus being fraught with low reproducibility, especially in cases of atypical hyperplasia and well differentiated carcinomas . With the method becoming widely accepted, new reporting formats specially designed for cytologic material have already been proposed …”

“…A new system for cytological reporting of endometrial samples was used, as previously described . It has six diagnostic categories: (1) nondiagnostic/unsatisfactory; (2) without evidence of hyperplasia or malignancy; (3) ACE‐U (atypical cells of endometrium of undetermined significance); (4) ACE‐L (atypical cells of endometrium with low probability for malignancy); (5) ACE‐H (atypical cells of endometrium with high probability for malignancy); and (6) malignant.…”

Moving Toward a Systematic Approach for Reporting Salivary Gland Cytopathology: An Institutional Experience and Literature Review

“…Several cytology reporting systems have been proposed and used in practice, including the current Bethesda System for Reporting Thyroid Cytopathology, 10 the Paris System for Reporting Urinary Cytology, 11 a recently proposed system for reporting endometrial cytology, 12 and the current Bethesda System for Reporting Cervical Cytology. 13 Although these reporting systems were originally designed to report cytopathology of different organs, the diagnostic Abbreviations: FNA, fine-needle aspiration; NPV, negative predictive value; PPV, positive predictive value; Sen, sensitivity; Spe, specificity.…”

Image analysis and multi‐layer perceptron artificial neural networks for the discrimination between benign and malignant endometrial lesions

“…As an alternative, pipelle biopsy along with cytology represents a minimally invasive method for the early detection of the disease . In the case of endometrial cytology, however, several factors are limiting the diagnostic accuracy of the method, including the amount of remaining cells on the sampling device and the presence of protein, mucus and blood, which often contaminates the specimens . Liquid‐based cytology (LBC) represents a novel method of cytological analysis which overcomes these barriers: the technique allows cytomorphological evaluation of nuclear features, including geometric and densitometric analysis …”