2011
DOI: 10.1159/000323411
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A Reproducible Porcine Model of Acute Liver Failure Induced by Intrajejunal Acetaminophen Administration

Abstract: Background and Aims: Severe intoxication following acetaminophen overdose is the most common cause of acute liver failure (ALF) in many Western European and North American countries. A reproducible large animal model of acetaminophen intoxication has not been successfully evaluated previously. Methods: Eight male pigs underwent acetaminophen intoxication receiving an initial enteric bolus of 250 mg/kg body weight acetaminophen followed by an acetaminophen plasma level (300–450 mg/l) adapted enteric maintenance… Show more

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Cited by 16 publications
(19 citation statements)
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“…The high reproducibility of ALF resulting in 100% mortality due to multiple-organ failure confirmed the results of the our previously published porcine model of acetaminophen intoxication[17]. Within the current experimental setting, continuous venovenous hemofiltration was administrated in addition to standardized intensive care therapy in order to maximally prolong survival in ALF for patients after massive acetaminophen overdose[19].…”
Section: Discussionsupporting
confidence: 67%
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“…The high reproducibility of ALF resulting in 100% mortality due to multiple-organ failure confirmed the results of the our previously published porcine model of acetaminophen intoxication[17]. Within the current experimental setting, continuous venovenous hemofiltration was administrated in addition to standardized intensive care therapy in order to maximally prolong survival in ALF for patients after massive acetaminophen overdose[19].…”
Section: Discussionsupporting
confidence: 67%
“…Dosage, administration and acetaminophen plasma level monitoring for a reproducible onset of acute liver failure after intrajejunal acetaminophen intoxication has been previously described in detail[17]. In brief, six pigs (6/8) received an initial enteric acetaminophen bolus of 250 mg/kg body weight via the implanted jejunal catheter.…”
Section: Methodsmentioning
confidence: 99%
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