A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

Fang, Evandro Fei; Xie, Chenglong; Schenkel, Joseph Adam; Wu, Chenkai; Long, Qian; Cui, Honghua; Aman, Yahyah; Frank, Johannes; Liao, Jing; Zou, Huachun; Wang, Ninie Y.; Wu, Jing; Liu, Xiaoting; Li, Tao; Fang, Yuan; Niu, Zhangming; Yang, Guang; Hong, Jiangshui; Wang, Qian; Chen, Guobing; Li, Jun; Chen, Hou-Zao; Kang, Lin; Su, Huanxing; Gilmour, Brian C.; Zhu, Xinqiang; Jiang, Hong; He, Na; Tao, Jun; Leng, Sean X.; Tong, Tanjun; Woo, Jean

doi:10.1016/j.arr.2020.101174

Cited by 385 publications

(238 citation statements)

References 223 publications

(179 reference statements)

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“…Declining fertility rates and rising life expectancy are increasing the median age in countries worldwide. The proportion of older persons aged 65 or over is projected to reach nearly 12% in 2030 and 16% in 2050 (1) and it is predicted that there will be 365 million Chinese citizens aged ≥65 (26.1% of the total population) by 2050 (2). With this, the prevalence of multiple chronic comorbidities and polypharmacy are expected to increase (3).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of potentially inappropriate medications prescribing in elderly patients in Chinese communities

Li¹,

Hu²,

Gao³

et al. 2021

Ann Palliat Med

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Background: To assess the prevalence and associated risk of potentially inappropriate medications (PIMs) prescribing in community-dwelling elderly patients in China and to examine the most frequently used PIMs. This will provide a reference for the formulation of medication manuals for the community-dwelling elderly and further standardize the use of medications in elderly patients.Methods: We conducted a cross-sectional retrospective study from April 1, 2020 to April 30, 2020. Data from elderly patients aged ≥65 years were collected from the Hengjie (N=2,294), Loujiang (N=3,972), and Tongxing communities (N=1,969) in Suzhou. The frequency of PIMs was detected using the 2019 Beers criteria and the 2017 Chinese criteria. Chi-square (for categorical variables), ANOVA (for continuous variables as applicable), and logistic regression were used to describe and identify potential predictors of PIMs.Results: A total of 8,235 elderly patients were examined. Using the Chinese criteria, the prevalence of PIMs was 37.07%, which was slightly higher than that found using the 2019 Beers criteria (32.16%).The most prescribed PIMs were estazolam (21.53%) and insulin (4.60%) based on the Chinese criteria.Logistic regression analysis showed that advanced age, polypharmacy, and comorbid disease of patients were associated with a high risk of PIMs. Furthermore, the educational background and professional title of physicians were also associated with PIMs.Conclusions: Given the high prevalence of PIMs in the Chinese community-dwelling elderly population, the implementation of evidence-based interventions to promote rational clinical drug use could improve their quality of life.

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Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of potentially inappropriate medications prescribing in elderly patients in Chinese communities

Li¹,

Hu²,

Gao³

et al. 2021

Ann Palliat Med

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“…Population aging is a global phenomenon [ 1 ]. In China, people aged 65 years and above made up 13.5% of the total population in 2020 [ 2 ] and the proportion is still increasing [ 3 ]. Due to the development of the economy and technology, life expectancy continues to increase [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Diversity and Healthy Aging: A Prospective Study

Zhang

Zhao

2021

Nutrients

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Population aging is a global phenomenon. The present study determined the effects of dietary diversity score (DDS) and food consumption on healthy aging. A subset of the data of the China Health and Nutrition Survey was utilized in this study. DDSs were calculated using the dietary data collected in the years 2009 and 2011. A healthy aging score (HAS) was calculated by summing the standardized scores on physical functional limitation, comorbidity, cognitive function, and psychological stress based on the data collected in the year 2015, with a lower HAS indicating a healthier aging process. Life quality was self-reported in the year 2015. This study found that DDS was inversely associated with HAS (T3 vs. T1: β −0.16, 95%CI −0.20 to −0.11, p-trend <0.001). The consumption of meat and poultry, aquatic products, and fruits was inversely associated with HAS, and participants in the highest tertile of staple foods consumption had a higher HAS than those in the lowest tertile. HAS was inversely associated with good self-reported life quality and positively associated with bad life quality. In conclusion, food consumption may influence the aging process, and adherence to a diverse diet is associated with a healthier aging process in elderly people.

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“…Furthermore, ageing itself and its resulting MCDs have been shown to accelerate the simultaneous occurrence of stroke and functional disability [14]. Given that population ageing continues to increase in China [17], studies addressing functional disability in elderly stroke patients are warranted.…”

Section: Introductionmentioning

confidence: 99%

Combined Association of Multiple Chronic Diseases and Social Isolation With Functional Disability in Elderly Stroke Patients: A Multicentre Cross-sectional Study in China

Liu¹,

Yu²,

Gao³

et al. 2021

Preprint

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BackgroundMultiple chronic diseases (MCDs) and social isolation are independent risk factors related with stroke and disability, but it is unknown whether the combination of these two conditions resulted from ageing related to functional disability in stroke patients. The purpose of this study was to probe the relationship between combination of MCDs, social isolation and functional disability in elderly stroke patients.MethodsA multicentre and cross-sectional study was conducted in the Departments of Rehabilitation Medicine of 103 hospitals located in 23 cities across China. Stroke patients aged over 60 years were selected as participants. Demographic characteristics, lifestyles and clinical information were investigated by questionnaire and medical records. Multi-nominal logistic regression model was used to explore the association of MCDs, social isolation and their combination with functional disability assessed by Barthel Index Scale.ResultsA total of 4281 elderly stroke patients were included in the final analysis. The proportion of social isolation and MCDs (>1) increased by the severity of functional disability. Social isolation was associated with increased risks for mild (33%), moderate (175%), and severe (833%) functional disability significantly in their comparisons with those without social isolation and MCDs. The intragroup odds ratio (OR) of MCDs increased by its number and the intergroup of OR increased by the severity of functional disability significantly. Social isolation and ≥3 MCDs associated the highest risk for severe (OR= 38.24, 95%CI: 14.76-99.07) and moderate (OR = 9.74, 95%CI: 3.62-26.22) functional disability, but not significant for mild group.ConclusionsMCDs, social isolation, and their combination were associated with functional disability in Chinese elderly stroke patients. Future secondary prevention and rehabilitation for functional disability in this population should underscore both social activity and the combined treatments of MCDs.Clinical Trial Registration NOChiCTR2000034067.

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A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

Cited by 385 publications

References 223 publications

Prevalence and determinants of potentially inappropriate medications prescribing in elderly patients in Chinese communities

Prevalence and determinants of potentially inappropriate medications prescribing in elderly patients in Chinese communities

Dietary Diversity and Healthy Aging: A Prospective Study

Combined Association of Multiple Chronic Diseases and Social Isolation With Functional Disability in Elderly Stroke Patients: A Multicentre Cross-sectional Study in China

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