This study aims to construct a depth-discharge relation for inundation simulation in the Mekong River considering hydraulic resistance. This relation links to the conveyance capacity of a river channel, one of the key components of inundation models, which means that understanding of the relation is necessary to conduct inundation simulation. A depth-discharge rating curve is constructed based on the simple assumption that discharge increases in a simple increasing function as depth increases. However, it is well recognized that this assumption is not valid in some cases: e.g., 1) rating curves constructed with only small-scale flood data are not always readily applicable to larger floods since extrapolation is often needed in this case, generally causing inaccurate estimation, and 2) rating curves cannot be maintained when river bed elevation changes, which means that they need to be checked periodically. One of the reasons for these cases is that hydraulic resistance varies as river bed shear stress changes during a flood. Accordingly, construction of the depth-discharge relation requires the knowledge of fluvial hydraulics, e.g., bed form and hydraulics resistance which is composed of velocity, water depth, hydraulic slope and bed material. A number of studies have been conducted on the relation between micro-scale bed form and hydraulic resistance. Engelund focused on the relation between dimensionless total and grain shear stress (the ' * * * * relation. They also formulated a bed roughness (n 1) for each bed form. Yamamoto developed diagrams which indicate the relation among velocity factor, dimensionless total shear stress, and relative water depth. * * * * relation reproduce the discharges observed by ADCP in 2009. In addition, the calculated discharge with roughness composed of only grain roughness reproduces the peak discharge in 2011 estimated by the Mekong River Commission. The results will be useful to estimate discharges as a boundary condition. Moreover, the knowledge acquired in this study will help modeling bed roughness with respect to hydraulic force for further study related to inundation simulation.