A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis

Chen, Chien Hua; Lin, Cheng Li; Hsu, Chung Y.; Kao, Chia Hung

doi:10.1080/03007995.2018.1508011

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Hypereosinophilia is a common phenomenon which has a protective effect in the process of parasitic infection. It can lead to inflammation and damage of affected biliary tree and promote the development of cholelithiasis (Chen et al ., 2019). This also indicates that C. sinensis infection may be closely related to eosinophil count and cholelithiasis.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between chronic C. sinensis infection and cholelithiasis has been reported in several studies (Choi et al ., 2008, 2012; Qiao et al ., 2014; Chen et al ., 2019), though other investigations have found no significant relationship between cholelithiasis and clonorchiasis (Hou et al ., 1989; Kim et al ., 2009). In most of these prior studies, there were insufficient samples of patients infected with C. sinensis .…”

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confidence: 89%

“…The presence of gallstones in clonorchiasis has been documented and the patients with calcium carbonate gallbladder stones have been reported to have higher infection rate of C. sinensis (Ma et al ., 2015). Furthermore, accumulating studies have shown that cholelithiasis is closely associated with chronic C. sinensis infection (Choi et al ., 2008; Chen et al ., 2019).…”

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confidence: 99%

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Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China

Xie¹,

Deng

Chen³

et al. 2019

J. Helminthol.

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The association between eosinophil count and cholelithiasis among people with Clonorchis sinensis infection is still uncertain. We conducted a cross-sectional study to investigate the associations among Clonorchis sinensis infection, eosinophil count and cholelithiasis. The study included 4628 participants from January to December 2018. The levels of eosinophil count were divided into four groups according to the quartiles of eosinophil count. Spearman's rank correlation was performed to assess the association between eosinophil counts and Clonorchis sinensis egg counts. Multiple regression analysis was performed to evaluate the relationships among C. sinensis infection, eosinophil count and cholelithiasis after adjusting for three models. The prevalence of C. sinensis infection was 38.72% (1792/4628), and the prevalence of cholelithiasis was 6.03% (279/4628). The infection rate of C. sinensis was higher in the cholelithiasis group than in the non-cholelithiasis group (63.08% vs. 37.16%, P < 0.001). Significant differences were found among various eosinophil count quartiles for C. sinensis infection, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltranspeptidase (γ-GT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA) and non-alcoholic fatty liver disease (NAFLD) (all P < 0.001). A significant positive correlation was found between eosinophil count and log-transformed C. sinensis egg count (r = 0.9477, P < 0.001). Multiple logistic regression analysis revealed that light and moderate intensities of C. sinensis infection were associated with cholelithiasis (P < 0.01 and P < 0.001, respectively), and C. sinensis infection with eosinophil count ranging from 0.05 to 0.5 × 109/l were associated with cholelithiasis (P < 0.05). In conclusion, our findings suggest that the light and moderate infections of C. sinensis with eosinophil count ranging from 0.05 to 0.5 × 109/l may be associated with a higher risk of cholelithiasis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 89%

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confidence: 99%

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Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China

Xie¹,

Deng

Chen³

et al. 2019

J. Helminthol.

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Hepatolithiasis pathogenesis update

Lu,

Li,

Yang

et al. 2024

Hepatology Research

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Hepatolithiasis is prevalent in East Asian countries and not common in Western countries. In recent years, because of the increased number of immigrants from East Asia in Western countries, hepatolithiasis has gradually become a global problem. Although current surgical interventions for hepatolithiasis boast a high rate of stone clearance, the persistent challenges of the disease's refractory nature and high recurrence rate continue to complicate its treatment. Therefore, understanding its underlying pathogenesis is meaningful for effective treatment. In this review, we discuss the common risk factors: infection, cholangitis, environmental factors and diet habits, abnormal bile components, anatomical abnormalities, and bile stasis, and summarize the relevant mechanisms.

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A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis

Cited by 2 publications

References 27 publications

Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China

Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China

Hepatolithiasis pathogenesis update

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