A retrospective analysis of 82 cases of cancer of the penis

Lindegaard, J.C.; Nielsen, Ole Skat; Lundbeck, Finn; Mamsen, Astrid; Studstrup, H.N.; Maase, Hans von der

doi:10.1046/j.1464-410x.1996.02221.x

Cited by 40 publications

(9 citation statements)

References 6 publications

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“…Thus, close follow‐up is needed. Fortunately, salvage surgery has a high success rate and does not affect CSS . This strategy is offered to patients with well differentiated tumours, absence of concurrent Tis and an otherwise normal looking glans.…”

Section: Organ‐preserving Strategies Based On Disease Stage and Locationmentioning

confidence: 99%

Penile cancer: organ‐sparing techniques

et al. 2014

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To compare the oncological safety of treating patients with penile cancer with conservative techniques developed to preserve function, cosmesis and psychological well‐being with more radical ablative strategies. We conducted an extensive review of the literature of penile‐preserving and ablative techniques and report on the oncological as well as functional outcomes. There were no randomised studies comparing penile‐preserving and ablative techniques. Most studies consisted of retrospective cohorts. The quality of evidence was level 3 at best. Cancer‐specific survival is similar in penile‐preserving and ablative approaches for low‐stage disease. Penile preservation is better for functional and cosmetic outcomes and should be offered as a primary treatment method in men with low‐stage penile cancer.

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Section: Organ‐preserving Strategies Based On Disease Stage and Locationmentioning

confidence: 99%

Penile cancer: organ‐sparing techniques

et al. 2014

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“…Lokalrezidive treten stadien-und therapieabhängig in bis zu 50% der Fälle auf,wobei sich die Mehrzahl der Rezidive innerhalb von 3 Jahren nach Diagnose zeigt [1,12,14,18]. …”

Section: Schlüsselwörterunclassified

“…Bei ten mit einem G2-oder G3-Tumor Lymphknotenmetastasen aufwiesen. Diese Prognosefaktoren sind für die 5-Jahres-Überlebensrate von Bedeutung, wobei ein positiver Lymphknotenstatus per se natürlich ebenfalls prognostisch ungünstig ist [14,28,30,38]. Für die Prognose des Patienten wird von den meisten Autoren auf die Bedeutung der Lymphknotenbeteiligung als wichtigsten prognostischen Faktor hingewiesen.…”

Section: Größere T1- T2-und Distale T3-tumorenunclassified

Operative Therapie des Peniskarzinoms

Doehn¹,

Baumgärtel²,

Jocham³

2001

Der Urologe A

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Primary therapy of penile cancer (carcinoma in situ/T1 tumors) consists of circumcision, microsurgical excision, application of 5-fluorouracil cream, radiation, or laser treatment. In cases of larger T1 tumors or T2 and distal T3 tumors, partial penectomy with a 2-cm margin of clearance is mandatory. Secondary therapy includes inguinal lymphadenectomy 4-6 weeks after primary treatment and antibiotic prophylaxis. Independent prognostic factors for the presence of lymph node metastases are T stage and grading. Only patients with noninvasive G1 or G2 tumors and nonpalpable inguinal lymph nodes are candidates for surveillance with careful follow-up. Inguinal lymphadenectomy is performed in a radical or modified (Catalona) manner. Sentinel biopsy (Cabanas) may regain importance with the use of gamma probes. Complication rates of inguinal lymphadenectomy correlate to the extent of the procedure and must be weighed against the possibility of cure with lymphadenectomy. In cases of inguinal lymph node metastasis, removal of the iliac lymph nodes (one- or two-step procedure) is necessary.

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“…Größere Tumoren werden in der Regel nicht organerhaltend, sondern durch partielle oder totale Penektomie behandelt [11]. Die Strahlentherapie als organerhaltendes Therapieverfahren kann in kurativer Intention bei T1-und gut differenzierten T2-Peniskarzinomen, die nicht größer als 4 cm sind, eingesetzt werden.…”

Section: Indikationenunclassified

Strahlentherapie des Peniskarzinoms

Mahlmann¹,

Doehn²,

Feyerabend³

2001

Der Urologe A

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Penile cancer is rare. Thus, there are no therapeutic recommendations fulfilling the requirements of evidence-based medicine. The empirically based therapeutic approach consists of local excision, laser therapy, or radiotherapy with comparable local control rates. Radiation is delivered by external beam radiotherapy or as brachytherapy. After radiotherapy, 5-year survival rates of 66-92% and organ preservation in 55-84% are reported. Serious long-term sequelae are necrosis (3-23%) and urethral stenosis (6-45%) requiring surgery. In the adjuvant treatment of the locoregional lymph nodes, lymphadenectomy and radiotherapy of both inguinal regions are therapeutic options. Inguinal lymph node metastases may be irradiated pre- or postoperatively to reduce the local recurrence rates. In addition, palliative radiotherapy of the primary tumor, lymph node, or distant metastases is of use for incurable patients. New combined therapies, e.g., radiochemothermotherapy, are currently under clinical evaluation and may offer a curative and organ-preserving therapeutic option to patients with locally advanced tumors.

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A retrospective analysis of 82 cases of cancer of the penis

Cited by 40 publications

References 6 publications

Penile cancer: organ‐sparing techniques

Penile cancer: organ‐sparing techniques

Operative Therapie des Peniskarzinoms

Strahlentherapie des Peniskarzinoms

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