A retrospective analysis of cervical smears for detection of precancerous lesions

Abstract

Background: Diseases of the cervix are common in women. Detection of neoplastic lesions is of prime importance in the evaluation of cervical smears although their frequency is less than the non-neoplastic conditions. Reactive and inflammatory conditions, however, may mimic or obscure the dysplastic changes. The aim of this study was to evaluate the frequencies of various inflammatory, reactive and neoplastic lesions in the cervical smears.Materials and Methods: This was a retrospective study of 150 cases of cervical smears collected from medical record section of the hospital and Department of Pathology at National Medical College from April 2013 to April 2015.Results: Of 150 patients who underwent cervical cytology, only 15 cases (10%) had epithelial cell abnormalities. This was followed by reactive cellular changes associated with inflammation (16.7%), infections (5.3%) and atrophy (1.3%). Low grade squamous intraepithelial lesion (6%) was the most common epithelial cell abnormality followed by high grade squamous intraepithelial lesion (2%), atypical glandular cells (1.3%) and squamous cell carcinoma (0.7%).Conclusion: Reactive changes including atrophy were the commonest finding. Squamous intraepithelial lesion was commonest finding among epithelial abnormalities. Glandular intraepithelial lesions and squamous cell carcinoma were also identified. Among infections Trichomoniasis and candidiasis were seen.

Abnormal Pap Smear Results in Outpatient Attendees in a Tertiary Care Center in Kathmandu, Nepal

“…In our study, 3.6% of sample ware excluded from study due to sample inadequacy or being unsatisfactory which was lower than reported by 16,17,19,22,23 Bacterial vaginosis (1.9%) was the commonest organism isolated in our study which is same as reported by other studies done in Nepal and India. The percentage reported in these study vary from 3.3% to 7.6%.…”

“…The percentage reported in these study vary from 3.3% to 7.6%. 16,21,22 Trichomonas was the next common organism reported on this study. The reason for lower percentage of infections in this study could be due to the fact that all women with obvious sign of infection during Pap smear were treated for their infection prior to taking sample.…”