A retrospective analysis of possible triggers of Guillain–Barre syndrome

Yang, Bing; Lian, Ying; Liu, Ying; Wu, Bing-yun; Duan, Rui‐Sheng

doi:10.1016/j.jneuroim.2016.02.003

Cited by 32 publications

(30 citation statements)

References 42 publications

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“…Subsequently, we reviewed the electrophysiological features of post-traumatic GBS in the literature and found that after trauma, the axonal subtype of GBS is more common than the demyelinating subtype (Table 4 ). Yang et al retrospectively analyzed 36 adult patients with GBS and found that the axonal subtype of GBS in post-trauma patients was proportionally higher than that in non-trauma patients, as seen in the present study [ 23 ]. The limited number of case reports of post-traumatic GBS in the literature does not support the conclusion that a causal relationship exists between the clinical phenotype and the history of trauma.…”

Section: Discussionsupporting

confidence: 74%

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Xiao

Ding

et al. 2017

BMC Neurol

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BackgroundPost-traumatic Guillain-Barré syndrome (GBS) is a rarely described potentially life-threatening cause of weakness. We sought to elucidate the clinical features and electrophysiological patterns of post-traumatic GBS as an aid to diagnosis.MethodsWe retrospectively studied six patients diagnosed with post-traumatic GBS between 2014 and 2016 at Tianjin Medical University General Hospital, China. Clinical features, serum analysis, lumbar puncture results, electrophysiological examinations, and prognosis were assessed.ResultsAll six patients had different degrees of muscular atrophy at nadir and in two, respiratory muscles were involved. Five also had damaged cranial nerves and four of these had serum antibodies against gangliosides. The most common electrophysiological findings were relatively normal distal latency, prominent reduction of compound muscle action potential amplitude, and absence of F-waves, which are consistent with an axonal form of GBS.ConclusionsIt is often overlooked that GBS can be triggered by non-infectious factors such as trauma and its short-term prognosis is poor. Therefore, it is important to analyze the clinical and electrophysiological features of GBS after trauma. Here we have shown that electrophysiological evaluations are helpful for diagnosing post-traumatic GBS. Early diagnosis may support appropriate treatment to help prevent morbidity and improve prognosis.

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Section: Discussionsupporting

confidence: 74%

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Xiao

Ding

et al. 2017

BMC Neurol

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“…2 However, GBS has also been reported to be triggered by non-infectious factors such as trauma, vaccination, autoimmune diseases, immunosuppression and administration of ganglioside. 3,4 Two publications from Mayo Clinic and Massachusetts General Hospital firstly reported surgical procedures as a trigger for GBS. 5,6 Since then, there have been a large number of published case reports on GBS triggered by surgery.…”

Section: Introductionmentioning

confidence: 99%

<p>Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes</p>

Bao

Zhang

et al. 2020

NDT

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Background: Surgery-related Guillain-Barré syndrome (GBS) is often underestimated and sometimes difficult to diagnose. This study aimed to elucidate the clinical features and electrophysiological subtypes of post-surgical GBS. Methods: We retrospectively reviewed 17 patients who developed post-surgical GBS after a recent surgery between 2015 and 2019. Clinical characteristics, electrophysiological examinations, lumbar puncture results and prognosis were assessed. As controls, we selected 66 patients hospitalized with non-surgical GBS. Results: The median duration from the surgery to the onset of GBS symptoms was 16.0 days. The main types of surgeries preceding GBS were orthopedic, gastrointestinal and neurosurgery. Symmetrical distal limbs weakness was present in all 17 post-surgical GBS patients. The incidence of respiratory failure, autonomic dysfunction and muscle atrophy in post-surgical GBS patients was significantly higher than that in non-surgical GBS patients. Hughes Functional Grading Scale (HFGS) scores were also higher in the post-surgical GBS group both at the time of peak disease and 6 months after discharge. Electrophysiological studies revealed significant motor amplitudes reduction with relative preserved nerve conduction velocities and distal latencies, suggesting axonal subtypes of GBS. Conclusion: GBS should be considered in patients with rapidly progressive muscle weakness after surgery. Such patients often exhibit axonal subtypes of GBS with severe motor dysfunction, high risk of respiratory failure, and poor prognosis.

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“…In addition to acute gastroenteritis, campylobacteriosis may result in severe autoimmune sequelae, including reactive arthritis and in about one of every 1,000 cases, Guillain-Barré syndrome (GBS). Campylobacteriosis is considered to be the most frequent antecedent for GBS (9,10).…”

mentioning

confidence: 99%

The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms

Bolinger

Kathariou

2017

Appl Environ Microbiol

131

137

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spp., especially and, are leading bacterial foodborne pathogens worldwide. In the United States, an estimated 0.8 million cases of campylobacteriosis occur annually, mostly involving Campylobacteriosis is generally self-limiting, but in severe cases, treatment with antibiotics may be mandated. The increasing incidence of fluoroquinolone resistance in has rendered macrolides such as erythromycin and azithromycin the drugs of choice for human campylobacteriosis. The prevalence of macrolide resistance in remains low, but macrolide resistance can be common in Substitutions in the 23S rRNA gene, specifically A2075G, and less frequently A2074C/G, remain the most common mechanism for high-level resistance to macrolides. In , resistance mediated by such substitutions is accompanied by a reduced ability to colonize chickens and other fitness costs, potentially contributing to the low incidence of macrolide resistance. Interestingly, similar fitness impacts have not been noted in Also noteworthy is a novel mechanism first reported in 2014 for a isolate from China and mediated by(B) harbored on multidrug resistance genomic islands. The incidence of (B) appears to reflect clonal expansion of certain strains, and whole-genome sequencing has been critical to the elucidation of(B)-associated macrolide resistance in spp. With the exception of one report from Spain,(B)-mediated macrolide resistance has been restricted to spp., mostly, of animal and human origin from China. If (B)-mediated macrolide resistance does not confer fitness costs in, the range of this gene may expand in , threatening to compromise treatment effectiveness for severe campylobacteriosis cases.

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A retrospective analysis of possible triggers of Guillain–Barre syndrome

Cited by 32 publications

References 42 publications

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

<p>Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes</p>

The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms

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