A retrospective analysis of the effect of salpingectomy on serum antiMüllerian hormone level and ovarian reserve

Ye, Xuping; Yang, Yuan-Jian; Sun, Xiaoxi

doi:10.1016/j.ajog.2014.07.027

Cited by 86 publications

(109 citation statements)

References 28 publications

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“…A recent move towards early bilateral salpingectomy as an alternative option is not well studied and its effect on ovarian aging unclear. Retrospective and crosssectional studies of women presenting for in vitro fertilization have demonstrated lower AMH and higher FSH levels in women who had undergone bilateral salpingectomy compared to untreated women 8,9 . In light of the evidence that even a simple hysterectomy and other forms of minor ovarian surgery, such as drilling, bring forward the age of menopause, it is possible that a relatively 'benign' procedure such as tubal surgery may have a deleterious effect in a group of women already predisposed to an early menopause 10,11 .…”

Section: Anna Fenton and Nick Panay Editors-in-chiefmentioning

confidence: 99%

What influences the age of menopause?

Fenton¹,

Panay²

2015

Climacteric

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Section: Anna Fenton and Nick Panay Editors-in-chiefmentioning

confidence: 99%

What influences the age of menopause?

Fenton¹,

Panay²

2015

Climacteric

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“…For example, although tubal sterilization is a common, effective and safe contraception method, one potential complication is post-tubal ligation syndrome. Post-tubal ligation syndrome is characterized by one or more sequelae post-surgery, including abnormal bleeding or pain, changes in sexual behavior or emotional health, exacerbation of premenstrual symptoms, menstrual disturbances and early menopause (Williams et al, 1951;Muldoon, 1972;Stock, 1978;Cooper, 1983;Gentile et al, 1998;Grynnerup et al, 2013;Ye et al, 2015). A few groups have reported luteal deficiency or a reduction in progesterone production after tubal ligation (Donnez et al, 1980;Alvarez-Sanchez et al, 1981;Corson et al, 1981;Donnez et al, 1981;Helm and Sjöberg, 1986).…”

Section: Introductionmentioning

confidence: 99%

Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle

Zhu

Rashedi

et al. 2016

Mol. Hum. Reprod.

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STUDY QUESTION: Do interactions between human fallopian tube epithelium and murine follicles occur during an artificial reproductive cycle in a co-culture system in vitro?SUMMARY ANSWER: In a co-culture system, human fallopian tissues responded to the menstrual cycle mimetic by changes in morphology and levels of secreted factors, and increasing murine corpus luteum progesterone secretion.WHAT IS KNOWN ALREADY: The entire fallopian tube epithelium, including ciliated and secretory cells, can be regulated in the reproductive cycle. Currently, there are no in vitro culture models that can monitor fallopian tissues in real time in response to factors produced by the ovary. In addition, there are no reports on the impact of fallopian tissue on ovarian function during the menstrual cycle.STUDY DESIGN, SAMPLES/MATERIALS, METHODS: Human fallopian tissue (n = 24) was obtained by routine hysterectomies from women (aged 26-50 years, mean age = 43.6) who had not undergone exogenous hormonal treatment for at least 3 months prior to surgery. CD1 female mice were used for ovarian follicle isolation. The human fallopian epithelium layers were either co-cultured with five murine multilayer secondary follicles (150-180 μm follicles, encapsulated in one alginate gel bead) for 15 days or received stepwise steroid hormone additions for 13 days. The fallopian tissue morphology and cilia beating rate, as measured by an Andor Spinning Disk Confocal, were investigated. Oviduct-specific glycoprotein 1 (OVGP1), human insulin-like growth factor 1 (hIGF1), vascular endothelial growth factor A (VEGF-A) and interleukin 8 (IL8) as biological functional markers were measured either by ELISA or western blot to indicate dynamic changes in the fallopian epithelium during the reproductive cycle generated by mouse follicles or by stepwise steroid hormone induction. Three or four patients in each experiment were recruited for replicates. Data were presented as mean ± SD and further analyzed using one-way ANOVA followed by Tukey's multiple comparisons test. MAIN RESULTS AND THE ROLE OF CHANCE:The cultured fallopian tube epithelium responded to exogenous steroid hormone stimulation, as demonstrated by enhanced cilia beating rate (~25% increase, P = 0.04) and an increase in OVGP1 secretion (P = 0.02) in response to 1 nM estradiol (E 2 ) treatment when compared with 0.1 nM E 2 . Conversely, 10 nM progesterone plus 1 nM E 2 suppressed cilia beating rate by~30% (P = 0.008), while OVGP1 secretion was suppressed by 0.1 nM E 2 plus 50 nM progesterone (P = 0.002 versus 1 nM E 2 alone). Human fallopian tube epithelium was co-cultured with murine secondary follicles to mimic the human menstrual cycle. OVGP1 and VEGF-A secretion from fallopian tissue was similar with stepwise hormone treatment and when cultured with murine follicles. However, the secretion patterns of hIGF1 and IL8 differed in the luteal phase when comparing steroid treatment with follicle co-culture. In co-culture, hIGF1 secretion was suppressed in the luteal versus follicular phase (P = 0.005)...

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“…Although the ovarian blood supply is primarily from the ovarian artery, some of its supply may arise from the ascending branch of the uterine artery, which traverses the mesosalpinx [19]. Thus, there is a theoretical concern that salpingectomy can reduce ovarian blood supply and thereby compromise ovarian reserve [20]. A review of the published literature regarding the impact of laparoscopic salpingectomy on ovarian reserve and responsiveness is inconclusive regarding this point.…”

Section: Discussionmentioning

confidence: 98%

“…A review of the published literature regarding the impact of laparoscopic salpingectomy on ovarian reserve and responsiveness is inconclusive regarding this point. In their retrospective study of 193 women undergoing unilateral salpingectomy, bilateral salpingectomy, or no tubal surgery, Ye et al [20] found that salpingectomy was associated with decreased anti-M€ ullerian hormone (AMH) levels and increased FSH levels in women seeking in vitro fertilization treatment. Similarly, Gelbaya et al [21] showed that women undergoing salpingectomy for hydrosalpinges had higher basal FSH levels, lower antral follicle counts, and fewer oocytes retrieved compared with Table 5 Comparison women who did not undergo surgery.…”

Section: Discussionmentioning

confidence: 98%