A retrospective analysis of therapeutic drug exposures in New Zealand National Poisons Centre data 2018–2020

Kumpula, Eeva-Katri; Paterson, Daniel A.; Pomerleau, Adam C.

doi:10.1016/j.anzjph.2023.100027

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Helal et al found that acetaminophen was the most common agent of acute poisoning (13). A study in New Zealand described that the medicines most involved in medication poisoning were paracetamol, antidepressants, and quetiapine (14). In our results, medications were the most used group of substances (central nervous system depressants).…”

Section: Discussionsupporting

confidence: 57%

Principal causes of acute poisoning in an emergency service: Experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Hurtado,

Quintero,

Rodríguez

et al. 2023

Preprint

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Background Acute poisonings are a global public health problem, which implies costs and disease burden for society. In Colombia, there is a significant underreporting of data on acute poisoning and data gaps on the toxicological profile of the population. This study aims to identify the epidemiology of acute poisoning in a highly complex hospital in southwestern Colombia. Methods A descriptive study with retrospective data collection was performed. The variables were expressed through the measure of central tendency and dispersion. Categorical variables were described in proportions. Results A total of 406 patients were included. The median age was 31 years (IQR: 23–48), 56.2% were male, and only 19.2% had a history of mental illness. Suicidal intent represented 58.8% of the cases, and the most frequent route of exposure was the oral route (81.6%). The most prevalent groups of substances were pesticides (34.2%) and medicines (32%). The most common etiological agent was organophosphates (16.5%). Cholinergic toxidrome was the most common. The average stay in the ICU was 4.5 days (± 4.8), and the mortality was 4.2%. Conclusions The principal causes of acute poisoning were drugs and pesticides, with a predominant etiology of organophosphates and depressants of the central nervous system. There was a significant predominance of young male patients with suicidal intent, low mental disorders, elevated unemployment rate, and similar mortality reported in other studies. This study improves the knowledge about acute poisoning in southwestern Colombian to carry out multicenter analytics studies.

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Section: Discussionsupporting

confidence: 57%

Principal causes of acute poisoning in an emergency service: Experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Hurtado,

Quintero,

Rodríguez

et al. 2023

Preprint

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“…The second agent responsible for the poisoning was medications. A study in New Zealand described that the medicines most involved in medication poisoning were paracetamol, antidepressants, and quetiapine 12 . In the US, the annual report of the national poisoning data system informed that during 2021 the substances mainly involved were analgesics (11.2%), household cleaning substances (10.7%), cosmetic products (5.88%), antidepressants (5.61%) and antipsychotics (4.73%), predominating the group of medications 9 .…”

Section: Discussionmentioning

confidence: 99%

Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Hurtado,

Quintero,

Rodríguez

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Acute poisonings are a global public health problem, which implies costs and disease burden for society. In Colombia, there is a significant underreporting of data on acute poisoning and data gaps on the toxicological profile of the population. This study aims to identify the epidemiology of acute poisoning in a high-complexity hospital in southwestern Colombia. A descriptive study with retrospective data collection was performed. The variables were expressed through the measure of central tendency and dispersion. Categorical variables were described in proportions. A total of 406 patients were included. The median age was 31 years (IQR 23–48), 56.2% were male, and only 19.2% had a history of mental illness. Suicidal intent represented 58.8% of the cases, and the most frequent route of exposure was the oral route (81.6%). The most prevalent groups of substances were pesticides (34.2%) and medicines (32%). The most common etiological agent was organophosphates (16.5%). Cholinergic toxidrome was the most common. The average stay in the ICU was 4.5 days (± 4.8), and the mortality was 4.2%. The principal causes of acute poisoning were drugs and pesticides, with a predominant etiology of organophosphates and depressants of the central nervous system. There was a significant predominance of young male patients with suicidal intent, low mental disorders, elevated unemployment rate, and similar mortality reported in other studies. This study improves the knowledge about acute poisoning in southwestern Colombian to carry out multicenter analytic studies.

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“…There were signi cant regional and age differences in the types of drugs exposed. In New England, the most common substances exposed to children under 12 years old are acetaminophen and ibuprofen [15]. However, in the United States, the most common medications exposed to children are benzodiazepines, opioids, or acetaminophen.…”

Section: Discussionmentioning

confidence: 99%

Acute Poisoning in children in Chengdu, China: A Retrospective Study (2019- 2022)

Wang,

Liu,

Huang

2024

Preprint

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Understanding the characteristics of children with acute poisoning admitted to emergency departments is helpful to the pediatrician to identify and treat poisoning. This retrospective and descriptive study included 2036 cases aged from 0-14years admitted to the emergency department with a diagnosis of acute poisoning. The incidence was slightly higher in boys than girls (51.2% vs. 48.8%). The most common route of poisoning was the digestive system (99.3%), and the majority were accidental poisonings (92.7%). Drugs were the most common toxic substances (62.1%), followed by pesticides (12.4%) and household cleaners (8.8%). The proportion of toxic substances varied among different age groups, with household cleaners being the most common in infants, and pesticides in other age groups, excluding drugs. Young children accounted for most acute poisoning cases, mostly due to unintentional ingestion of a single substance. Female adolescents were the most common patients intentionally ingested toxic substances, mainly psychotropic drugs.

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A retrospective analysis of therapeutic drug exposures in New Zealand National Poisons Centre data 2018–2020

Cited by 5 publications

References 29 publications

Principal causes of acute poisoning in an emergency service: Experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Principal causes of acute poisoning in an emergency service: Experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Acute Poisoning in children in Chengdu, China: A Retrospective Study (2019- 2022)

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