A retrospective comparison of COVID-19 and seasonal influenza mortality and outcomes in the ICUs of a French university hospital

Marignan, Donatien de; Vacheron, Charles-Hervé; Ader, Florence; Lecocq, Maxime; Richard, Jean Christophe; Casalegno, Jean Sébastien; Couray-Targe, Sandrine; Argaud, Laurent; Rimmelé, Thomas; Aubrun, Frédéric; Dailler, Frédéric; Fellahi, J.-L.; Bohé, Julien; Piriou, Vincent; Allaouchiche, Bernard; Friggeri, Arnaud; Wallet, Florent

doi:10.1097/eja.0000000000001672

Cited by 9 publications

(11 citation statements)

References 51 publications

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“…Conversely, in a recent French study, De Marignan et al . [ 38 ] reported that COVID-19 patients had higher 90-day adjusted mortality in the ICU than influenza patients. However, the authors did not include patients hospitalised during the 2009 A H1N1 pandemic, a particularly severe form of ARDS.…”

Section: Discussionmentioning

confidence: 99%

Moderate-to-severe ARDS: COVID-19 patients compared to influenza patients for ventilator parameters and mortality

et al. 2023

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BackgroundThis study aimed to compare ventilatory parameters recorded the first days of ARDS, and mortality at day 60 between COVID-19 and influenza ARDS patients with PaO2/FiO2≤150 mmHg.MethodsWe compared 244 COVID-19 ARDS patients with 106 influenza ARDS patients. Driving pressure (DP), respiratory system compliance (CRs), ventilator ratio (VR), corrected minute ventilation (VEcorr), and surrogate of mechanical power [index=(4×DP)+respiratory rate] were calculated from day1 to day 5 of ARDS. A propensity score analysis and a principal component analysis (PCA) were performed.ResultsOn day 1 of ARDS, COVID-19 patients had significantly higher PaO2/FiO2ratio (median [IQR], 97 mmHg [79–129]versus83 [62.2–114]), p=0.001), and lower DP (13 cmH20 [11–16.0]versus14 [12.0–16.7], p=0.01), VR (2.08 [1.73–2.49versus2.52 [1.97–3.03], p<0.001), VEcorr (12.7 L·mn−1[10.2–14.9]versus14.9 [11.6–18.6], p<0.001), index (80 [70–89]versus84 [75–94], p=0.004). PCA demonstrated an important overlap of ventilatory parameters recorded on day 1 between the two groups. From day 1 to day 5 repeated values of PaO2/FiO2ratio, PaCO2, VR and VEcorr differed significantly between influenza and COVID-19 patients in the unmatched and matched populations. Mortality at day 60 did not differ significantly after matching (29%versus21.7%, p=0.43).ConclusionsVentilation was more impaired in influenza than in COVID-19 ARDS patients the first day of ARDS with important overlap of values. However, mortality at day 60 did not differ significantly in the matched population.

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Section: Discussionmentioning

confidence: 99%

Moderate-to-severe ARDS: COVID-19 patients compared to influenza patients for ventilator parameters and mortality

et al. 2023

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“…Follow-up was completed on June 4, 2020 for the 4 groups. The patients in the COVID-19 and influenza groups were originally included in a previous study by our group 9 .…”

Section: Methodsmentioning

confidence: 99%

“…Microsoft Inc., Redmond, W.A, USA). The methods for data collection and quality control have been previously described 9 . Methods used for detection of the 4 different viruses are detailed in the supplementary information.…”

Section: Methodsmentioning

confidence: 99%

Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

Grangier,

Vacheron,

De Marignan

et al. 2024

Sci Rep

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This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients. At admission, patients in the COVID-19 group were significantly less severe than the others according to the simplified acute physiology score-2 (SAPS-II) and sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, COVID-19 (sHR = 1.61; 95% CI 1.10; 2.36) and H1N1 (sHR = 1.87; 95% CI 1.20; 2.93) were associated with a statistically significant higher mortality while seasonal influenza was not (sHR = 0.93; 95% CI 0.65; 1.31), when compared to RSV. Despite occurring in more severe patients, RSV and seasonal influenza group appear to be associated with a more favorable outcome than COVID-19 and H1N1 groups.

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“…Patients in the pre-omicron group were younger and had fewer comorbidities than those in the remaining groups, consistent with the results of studies conducted during the initial stages of the pandemic. 11 12 13 14 15 16 Conversely, the baseline characteristics were similar between the omicron and influenza groups, with almost half of the patients aged ≥ 70 years and a high prevalence of comorbidities. The age distribution and prevalence of comorbidities varied among patients with the omicron variant and those with previous COVID-19 variants.…”

Section: Dicussionmentioning

confidence: 98%

“…However, such studies were conducted during the early stages of the pandemic when effective treatment strategies had not yet been developed, which limits the generalizability of the findings. 11 12 13 14 15 16 Therefore, an updated evaluation of this topic is required.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea

Sim,

Lee,

Yang

et al. 2024

J Korean Med Sci

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Background The advent of the omicron variant and the formulation of diverse therapeutic strategies marked a new epoch in the realm of coronavirus disease 2019 (COVID-19). Studies have compared the clinical outcomes between COVID-19 and seasonal influenza, but such studies were conducted during the early stages of the pandemic when effective treatment strategies had not yet been developed, which limits the generalizability of the findings. Therefore, an updated evaluation of the comparative analysis of clinical outcomes between COVID-19 and seasonal influenza is requisite. Methods This study used data from the severe acute respiratory infection surveillance system of South Korea. We extracted data for influenza patients who were infected between 2018 and 2019 and COVID-19 patients who were infected in 2021 (pre-omicron period) and 2022 (omicron period). Comparisons of outcomes were conducted among the pre-omicron, omicron, and influenza cohorts utilizing propensity score matching. The adjusted covariates in the propensity score matching included age, sex, smoking, and comorbidities. Results The study incorporated 1,227 patients in the pre-omicron cohort, 1,948 patients in the omicron cohort, and 920 patients in the influenza cohort. Following propensity score matching, 491 patients were included in each respective group. Clinical presentations exhibited similarities between the pre-omicron and omicron cohorts; however, COVID-19 patients demonstrated a higher prevalence of dyspnea and pulmonary infiltrates compared to their influenza counterparts. Both COVID-19 groups exhibited higher in-hospital mortality and longer hospital length of stay than the influenza group. The omicron group showed no significant improvement in clinical outcomes compared to the pre-omicron group. Conclusion The omicron group did not demonstrate better clinical outcomes than the pre-omicron group, and exhibited significant disease severity compared to the influenza group. Considering the likely persistence of COVID-19 infections, it is imperative to sustain comprehensive studies and ongoing policy support for the virus to enhance the prognosis for individuals affected by COVID-19.

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A retrospective comparison of COVID-19 and seasonal influenza mortality and outcomes in the ICUs of a French university hospital

Cited by 9 publications

References 51 publications

Moderate-to-severe ARDS: COVID-19 patients compared to influenza patients for ventilator parameters and mortality

Moderate-to-severe ARDS: COVID-19 patients compared to influenza patients for ventilator parameters and mortality

Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea

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