A Retrospective Comparison of the Efficacy of Embolization with Imipenem/Cilastatin and Microspheres in the Management of Chronic Shoulder Pain

Finas, Mathieu; Frandon, Julien; Gremen, Emeric; Horteur, Clément; Benassayag, Michaël; Lateur, Gabriel; Pailhé, Régis; Ferretti, Gilbert; Bellier, Alexandre; Ghelfi, Julien

doi:10.1007/s00270-023-03385-2

Cited by 3 publications

(1 citation statement)

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“…There are reports suggesting that although there is a tendency to think that the behavior of an embolic agent is the same regardless of the region where it is used, but it differs according to the joint, the vascular anastomoses, the collateral network, and the articular structures [ 15 , 16 ]. It is considered important to reveal the characteristics of embolic materials under biological conditions in the future.…”

Section: Discussionmentioning

confidence: 99%

In vitro study of the embolic characteristics of imipenem/cilastatin particles

Nakamura,

Yamamoto,

Fukunaga

et al. 2024

CVIR Endovasc

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Background Imipenem/cilastatin (IPM/CS) has long been administered intravenously as a carbapenem antibiotic. However, since this agent is poorly soluble in liquid, occasional reports have described its use as a short-acting, temporary embolic agent. The purpose of this study was to elucidate the characteristics of IPM/CS particles, which are thought to have pain-relieving effects against osteoarthritis-related pain, as an embolic agent. Methods Three aspects of IPM/CS as an embolic agent were evaluated in vitro: particle size; particle shape; and change in particle size over time. For particle size, the long diameter was measured. Results Mean particle size (n=244) was 29.2±12.0 µm (range, 1–60 µm). Shape (n=109) was round in 18.35%, elliptical in 11.93%, and polygonal in 69.72%, showing that most particles were polygonal. In observations of changes in particle size over time (n=9), particles had decreased to 75% of their original size at 82±10.7 min, 50% at 89.3±9.14 min, 25% at 91.3±8.74 min, complete dissolved at 91.8±9.02 min. A rapid shrinkage in diameter was seen in the final period. Conclusions IPM/CS particles are ultrafine and the majority display a polygonal shape. This substance shows ultra-short embolic activity. This study revealed the characteristics of a substance that demonstrates an embolic effect not found in existing embolic materials.

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Section: Discussionmentioning

confidence: 99%