A Retrospective Evaluation of 51 Dogs with Insulinoma

Trifonidou, M A; Kirpensteijn, Jolle; Robben, Joris H.

doi:10.1080/01652176.1998.10807459

Cited by 54 publications

(88 citation statements)

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“…The Ki67 index has been correlated with clinical outcome in humans with insulinoma (La Rosa et al, 2009). The median disease free interval in 31 dogs that underwent partial pancreatectomy at Utrecht University was 244 days (range, 0 to 1116 days) and survival time was 258 days (range, 1 to 1146) (Tryfonidou et al, 1998). Polton and colleagues (2007) reported median survival time after diagnosis of 196 days (95% confidence interval [CI] 0 to 549 days) and 785 days (95% CI: 190 to 1380 days) in dogs treated medically versus dogs that initially underwent surgery followed by medical treatment, respectively.…”

Section: Prognosismentioning

confidence: 99%

Beta-Cell Neoplasia: Insulinoma

Nelson¹

2015

Canine and Feline Endocrinology

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Section: Prognosismentioning

confidence: 99%

Beta-Cell Neoplasia: Insulinoma

Nelson¹

2015

Canine and Feline Endocrinology

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“…Insulinomas are endocrine tumours of the pancreatic β‐cells that autonomously produce insulin, leading to hypoglycaemia and clinical signs that include exercise intolerance, seizures, muscle tremors, weakness and collapse (Leifer and others 1986, Mehlhaff and others 1995, Trifonidou and others 1998, Tobin and others 1999). Insulinomas are commonly observed in middle‐aged to older dogs (mean 7 years, range 5 to 12 years) of medium to large breeds.…”

Section: Introductionmentioning

confidence: 99%

“…Most canine insulinomas are malignant, infiltrating the local tissues and resulting in distant metastases. At the time of diagnosis, 40 to 50% of canine insulinomas have macroscopically visible metastases in the regional lymph nodes and liver (Leifer and others 1986, Trifonidou and others 1998).…”

Section: Introductionmentioning

confidence: 99%

Use of a bipolar vessel‐sealing device in resection of canine insulinoma

Wouters¹,

Buishand²,

Kik³

et al. 2011

J of Small Animal Practice

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“…[1][2][3] Over 95% of insulinomas in dogs are malignant, and 40-50% have visibly metastasized at the time of surgery. 2,4,5 Insulinomas are identified and staged by means of preoperative transabdominal ultrasonography (US) and, to a lesser extent, by computed tomography (CT) and by inspection and palpation during exploratory laparotomy.…”

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confidence: 99%

Comparison of Ultrasonography, Computed Tomography, and Single‐Photon Emission Computed Tomography for the Detection and Localization of Canine Insulinoma

Robbena

Pollak

Kirpensteijn

et al. 2005

Veterinary Internal Medicne

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Accurate preoperative detection, localization, and staging of the primary tumor and metastases are essential for the selection of appropriate candidates for surgery. In dogs with insulinoma, preoperative assessment usually is performed with transabdominal ultrasonography (US). There are no reports on the use of computed tomography (CT) for this purpose. The preoperative use of somatostatin receptor scintigraphy (SRS) recently has been advocated for the identification of insulinoma and gastrinoma in dogs, but its accuracy remains to be established. In this report US, CT, and single-photon emission computed tomography (SPECT) with [ 111 In-DTPA-D-Phe 1 ]-octreotide (a specific form of SRS) were compared for their effectiveness in detecting and localizing primary and metastatic insulinoma in dogs. Findings at surgery or postmortem examination served as control. Of 14 primary insulinomas, 5, 10, and 6 were correctly identified by US, CT, and SPECT, respectively. No lymph node metastases were detected by US or SPECT. CT identified 2 of 5 lymph node metastases but also identified 28 false-positive lesions. Two of 4 livers were found to be positive for metastases by 1 of the imaging techniques. US can be used for the initial evaluation of dogs with hypoglycemia. Although CT identifies most primary tumors, intraoperative inspection and palpation of the pancreas is still superior. SPECT appears as effective as US and CT in detecting insulinomas. Future developments in preoperative imaging techniques might improve current methods of canine insulinoma detection.Key words: Abdominal ultrasonography; Computed tomography; Diagnostic imaging; Dog; Pancreatic endocrine tumor; Somatostatin receptor scintigraphy. Insulin-producing pancreatic endocrine tumor, or insulinoma, is the most common of the 3 types of pancreatic endocrine tumor (PET) described in the dog (insulinoma, gastrinoma, and glucagonoma).1-3 Over 95% of insulinomas in dogs are malignant, and 40-50% have visibly metastasized at the time of surgery.2,4,5 Insulinomas are identified and staged by means of preoperative transabdominal ultrasonography (US) and, to a lesser extent, by computed tomography (CT) and by inspection and palpation during exploratory laparotomy.Data on the effectiveness of preoperative imaging techniques in dogs with insulinoma are limited to uncontrolled studies of transabdominal US. [6][7][8] In human medicine, several imaging techniques have been described and evaluated for preoperative identification and staging of PETs. Somatostatin receptor scintigraphy (SRS) has become an important and often 1st-line imaging method in humans with malignant PETs. [9][10][11][12] This imaging modality has a high sensitivity and a high specificity. [13][14][15] Additional advantages of this technique are whole-body scanning for extra-abdominal metastases, gamma probing for intraoperative identification of tumor foci, and selection of subjects suitable for treatment with a radiolabeled somatostatin analogue. otide was described for identification of insulinoma...

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A Retrospective Evaluation of 51 Dogs with Insulinoma

Cited by 54 publications

References 0 publications

Beta-Cell Neoplasia: Insulinoma

Beta-Cell Neoplasia: Insulinoma

Use of a bipolar vessel‐sealing device in resection of canine insulinoma

Comparison of Ultrasonography, Computed Tomography, and Single‐Photon Emission Computed Tomography for the Detection and Localization of Canine Insulinoma

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