A retrospective evaluation of the effect of perianesthetic hydromorphone administration on the incidence of postanesthetic signs of colic in horses

Skrzypczak, Heather; Reed, Rachel; Barletta, Michele; Quandt, Jane; Sakai, Daniel M.

doi:10.1016/j.vaa.2020.06.003

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…Nevertheless, in the present study, all horses continued to defecate, showed no signs of colic, and borborygmi scales were unaffected by treatment. These findings are in agreement with other studies of fentanyl in horses ( 5 , 8 , 9 , 16 ).…”

Section: Discussionsupporting

confidence: 93%

“…The AUCinf of 42.374 ng h/ml was slightly lower in the present study than the previous study that described 44.6–46.6 ng h/ml with placement of two patches ( 16 ). This is most likely attributed to differences in absorbance of fentanyl from the patch at the metatarsal location.…”

Section: Discussioncontrasting

confidence: 89%

“…In the present study, fentanyl administered via a transdermal matrix patch exhibited a dose dependent Cmax and AUCinf with similar terminal half-lives and clearance rates across all treatments. The pharmacokinetics of a single dose of fentanyl administered via a matrix patch have been previously described in a study investigating the effect of patch location by Skrzypczak et al ( 16 ). In that study, fentanyl from two 100 mcg/h patches was well absorbed at the metacarpus, tail, and inguinal abdominal region.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the plasma concentrations achieved were far lower than were targeted in the study design. The number of patches applied for each treatment were based on plasma concentrations achieved in previous studies using the same type of fentanyl matrix patch ( 16 ) with the aim of achieving the plasma concentration that was previously described as anti-nociceptive ( 5 ). If an additional eight or ten patch treatment group were included, then that plasma concentration may have been achieved and an anti-nociceptive effect observed.…”

Section: Discussionmentioning

confidence: 99%

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The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses

Reed,

Berghaus,

Reynolds

et al. 2024

Front. Pain Res.

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IntroductionUnderstanding the pharmacokinetics and pharmacodynamics of fentanyl in horses is crucial for optimizing pain management strategies in veterinary medicine.MethodsSix adult horses were enrolled in a randomized crossover design. Treatments included: placebo, two 100 mcg/h patches (LDF), four 100 mcg/h patches (MDF), and six 100 mcg/h patches (HDF). Patches were in place for 72 h. Blood was obtained for fentanyl plasma concentration determination, thermal threshold, mechanical threshold, heart rate, respiratory rate, and rectal temperature were obtained prior patch placement and at multiple time points following patch placement for the following 96 h. Fentanyl plasma concentration was determined using LC-MS/MS. Data were analyzed using a generalized mixed effects model.ResultsMean (range) maximum plasma concentration (Cmax), time to Cmax, and area under the curve extrapolated to infinity were 1.39 (0.82–1.82), 2.64 (1.21–4.42), 4.11 (2.78–7.12) ng/ml, 12.7 (8.0–16.0), 12.7 (8.0–16.0), 12 (8.0–16.0) h, 42.37 (27.59–55.56), 77.24 (45.62–115.06), 120.34 (100.66–150.55) h ng/ml for LDF, MDF, and HDF, respectively. There was no significant effect of treatment or time on thermal threshold, mechanical threshold, respiratory rate, or temperature (p > 0.063). There was no significant effect of treatment on heart rate (p = 0.364). There was a significant effect of time (p = 0.003) on heart rate with overall heart rates being less than baseline at 64 h.ConclusionsFentanyl administered via transdermal patch is well absorbed and well tolerated but does not result in an anti-nociceptive effect as measured by thermal and mechanical threshold at the doses studied.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses

Reed,

Berghaus,

Reynolds

et al. 2024

Front. Pain Res.

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“…Another known anaesthetic complication in horses, post‐anaesthetic colic (PAC) has been reported in 2.5%–18.5% of horses undergoing general anaesthesia (Borland et al, 2017; Jago et al, 2015; Skrzypczak et al, 2020; Thibault et al, 2019). There is limited evidence regarding the incidence of PAC in horses undergoing standing sedation for surgical and nonsurgical procedures.…”

mentioning

confidence: 99%

Is general anaesthesia avoidable for limb fracture repair in horses?

Loomes

Louro

2022

Equine Veterinary Education

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The case report by Aßmann et al. (2023) in this issue reported the surgical management of an accessory carpal bone fracture, repaired under standing sedation. This sets the tone for the debate between the risks and benefits of standing sedation versus general anaesthesia in horses undergoing fracture repair.It has been well documented that the risk of anaesthetic-related mortality in horses is high (

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Anesthetic Management for Laparoscopic and Thoracoscopic Procedures

Hector¹,

Hendrickson²

2022

Equine Anesthesia and Co‐Existing Disease

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A retrospective evaluation of the effect of perianesthetic hydromorphone administration on the incidence of postanesthetic signs of colic in horses

Cited by 14 publications

References 32 publications

The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses

The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses

Is general anaesthesia avoidable for limb fracture repair in horses?

Anesthetic Management for Laparoscopic and Thoracoscopic Procedures

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